Won't you be my neighbor? The importance of biogeography and nutrient niches in the gut.
Won't you be my neighbor? The importance of biogeography and nutrient niches in the gut.
复制标题
你不愿意做我的邻居吗？
DOI：
10.1016/j.chom.2022.05.009
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发表时间：
2022
影响因子：
30.3
通讯作者：
Zackular,JosephP
中科院分区：
文献类型：
--
作者：
Abbas,Arwa;Zackular,JosephP
微生物群组成的变化与许多人类疾病有关，但控制菌株丰度的因素仍然不明确。我们发现，共生的大肠埃希菌和致病性鼠伤寒沙门氏菌分离株都利用硝酸盐进行肠道生长，但各自在独特的生物地理生态位中获取这种资源。共生E. 大肠杆菌利用上皮来源的硝酸盐，而鼠伤寒沙门氏菌占据的生态位中的硝酸盐则来自吞噬细胞浸润。令人惊讶的是，无毒力的鼠伤寒沙门氏菌被证明不能利用上皮来源的硝酸盐，因为它的趋化性受体McpB和McpC将病原体排除在大肠杆菌占据的生态位之外。 大肠杆菌。相比之下，E. 大肠杆菌侵入由鼠伤寒沙门氏菌毒力因子构建的生态位，并通过竞争硝酸盐赋予定植抗性。因此，营养生态位不仅仅由关键资源定义，而是可以在宿主内根据生物地理进一步细分为不同的微生境，从而为不同的细菌物种产生新的生态位机会。
Changes in the microbiota composition are associated with many human diseases, but factors that govern strain abundance remain poorly defined. We show that a commensalEscherichia colistrain and a pathogenicSalmonella entericaserovar Typhimurium isolate both utilize nitrate for intestinal growth, but each accesses this resource in a distinct biogeographical niche. CommensalE. coliutilizes epithelial-derived nitrate, whereas nitrate in the niche occupied byS.Typhimurium is derived from phagocytic infiltrates. Surprisingly, avirulentS.Typhimurium was shown to be unable to utilize epithelial-derived nitrate because its chemotaxis receptors McpB and McpC exclude the pathogen from the niche occupied byE. coli. In contrast,E. coliinvades the niche constructed byS.Typhimurium virulence factors and confers colonization resistance by competing for nitrate. Thus, nutrient niches are not defined solely by critical resources, but they can be further subdivided biogeographically within the host into distinct microhabitats, thereby generating new niche opportunities for distinct bacterial species.