sLORETA allows reliable distributed source reconstruction based on subdural strip and grid recordings
sLORETA allows reliable distributed source reconstruction based on subdural strip and grid recordings
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DOI：
10.1002/hbm.21276
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发表时间：
2012-05-01
影响因子：
4.8
通讯作者：
Schulze-Bonhage, Andreas
中科院分区：
文献类型：
--
作者：
Duempelmann, Matthias;Ball, Tonio;Schulze-Bonhage, Andreas
基于硬膜下条和网格电极有创记录的源定位是一个越来越受关注的话题。本模拟研究解决的问题，哪些因素是相关的可靠的源重建的基础上sLORETA。接受侵入性术前癫痫诊断的患者的MRI和电极位置是sLORETA模拟的基础。一个边界元头部模型来自MRI用于模拟电位和源重建。分布在规则的三维格子上的焦偶极源和时空分布的补丁作为模拟的输入。除了原始和重建的源最大值之间的距离，激活体积的重建和原始和重建的源之间的时间过程的相关性进行了研究。通过定位患者的尖峰活动来补充模拟。对于无噪声的模拟数据，sLORETA实现了零定位误差的结果。添加的噪声降低了可靠的源定位的百分比，定位误差=15 mm至67.8%。仅对于靠近电极触点的源位置，激活体积才正确表示焦点发生器。原始源和重建源的时间进程显着相关。案例研究结果表明，准确的定位。sLORETA是一种分布式源模型，可用于可靠的基于网格和条带的源定位。对于远距离源位置，必须考虑对发生器范围的高估。基于sLORETA的源重建具有改善分布式发生器在术前癫痫诊断和认知神经科学中的定位的潜力。^Brain Mapp，2011. (c)2011 Wiley-Liss，Inc.
Source localization based on invasive recordings by subdural strip and grid electrodes is a topic of increasing interest. This simulation study addresses the question, which factors are relevant for reliable source reconstruction based on sLORETA. MRI and electrode positions of a patient undergoing invasive presurgical epilepsy diagnostics were the basis of sLORETA simulations. A boundary element head model derived from the MRI was used for the simulation of electrical potentials and source reconstruction. Focal dipolar sources distributed on a regular three-dimensional lattice and spatiotemporal distributed patches served as input for simulation. In addition to the distance between original and reconstructed source maxima, the activation volume of the reconstruction and the correlation of time courses between the original and reconstructed sources were investigated. Simulations were supplemented by the localization of the patient's spike activity. For noise-free simulated data, sLORETA achieved results with zero localization error. Added noise diminished the percentage of reliable source localizations with a localization error =15 mm to 67.8%. Only for source positions close to the electrode contacts the activation volume correctly represented focal generators. Time-courses of original and reconstructed sources were significantly correlated. The case study results showed accurate localization. sLORETA is a distributed source model, which can be applied for reliable grid and strip based source localization. For distant source positions, overestimation of the extent of the generator has to be taken into account. sLORETA-based source reconstruction has the potential to improve the localization of distributed generators in presurgical epilepsy diagnostics and cognitive neuroscience. Hum Brain Mapp , 2011. (c) 2011 Wiley-Liss, Inc.