CHANGED DISTRIBUTION OF SODIUM-CHANNELS ALONG DEMYELINATED AXONS
CHANGED DISTRIBUTION OF SODIUM-CHANNELS ALONG DEMYELINATED AXONS
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DOI：
10.1073/pnas.87.17.6777
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发表时间：
1990-09-01
影响因子：
11.1
通讯作者：
FINGER, TE
中科院分区：
文献类型：
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作者：
ENGLAND, JD;GAMBONI, F;FINGER, TE
电压门控性钠通道主要定位于有髓轴突的兰维尔结节，为跳跃性传导提供了生理基础。脱髓鞘轴突中的这些通道发生了什么还不确定。用一种特性良好的针对钠通道的多克隆抗体检测了实验性的脱髓鞘轴突。免疫细胞化学和放射免疫分析数据与先前结间轴突节段上钠通道数量增加的分布一致。这些发现肯定了脱髓鞘轴膜钠通道的可塑性，并可能与理解脱髓鞘后轴突如何恢复传导有关。
Voltage-gated sodium channels are largely localized to the nodes of Ranvier in myelinated axons, providing a physiological basis for saltatory conduction. What happens to these channels in demyelinated axons is not known with certainty. Experimentally demyelinated axons were examined by using a well-characterized polyclonal antibody directed against sodium channels. Immunocytochemical and radioimmunoassay data were consistent with the distribution of an increased number of sodium channels along segments of previously internodal axon. These findings affirm the plasticity of sodium channels in demyelinated axolemma and may be relevant to understanding how axons recover conduction after demyelination.