IL-10+ Innate-like B Cells Are Part of the Skin Immune System and Require α4β1 Integrin To Migrate between the Peritoneum and Inflamed Skin.
IL-10+ Innate-like B Cells Are Part of the Skin Immune System and Require α4β1 Integrin To Migrate between the Peritoneum and Inflamed Skin.
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IL-10+先天性B细胞是皮肤免疫系统的一部分，需要α4β1整合素才能在腹膜和发炎的皮肤之间迁移。
DOI：
10.4049/jimmunol.1403246
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发表时间：
2016-03-15
期刊：
影响因子：
--
通讯作者：
Debes GF
中科院分区：
文献类型：
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作者：
Geherin SA;Gómez D;Glabman RA;Ruthel G;Hamann A;Debes GF
皮肤是重要的屏障器官，也是自身免疫和变态反应的常见靶点。我们在人类和小鼠的皮肤中发现了表达抗炎细胞因子IL-10的先天性B细胞。出乎意料的是，先天样B1和传统的B2细胞表现出不同的归巢能力，腹膜B1细胞优先迁移到小鼠发炎的皮肤中。重要的是，皮肤归巢B1细胞包括IL-10分泌细胞。B1细胞归巢到皮肤中不依赖于典型的皮肤归巢运输受体，而是需要α4β1-整联蛋白。此外，B1细胞组成性表达活化的β1整合素，并在先天刺激后从腹膜重新定位至发炎的皮肤和肠道，表明其具有外渗至发炎和屏障部位的固有倾向。我们的结论是，先天性B细胞从中央水库迁移到皮肤，增加了一个重要的细胞类型的调节和保护功能的皮肤免疫系统。
The skin is an important barrier organ and frequent target of autoimmunity and allergy. Here we found innate-like B cells that expressed the anti-inflammatory cytokine IL-10 in the skin of humans and mice. Unexpectedly, innate-like B1 and conventional B2 cells showed differential homing capacities with peritoneal B1 cells preferentially migrating into the inflamed skin of mice. Importantly, the skin-homing B1 cells included IL-10 secreting cells. B1 cell homing into the skin was independent of typical skin-homing trafficking receptors and instead required α4β1-integrin. Moreover, B1 cells constitutively expressed activated β1 integrin and relocated from the peritoneum to the inflamed skin and intestine upon innate stimulation, indicating an inherent propensity to extravasate into inflamed and barrier sites. We conclude that innate-like B cells migrate from central reservoirs into skin, adding an important cell type with regulatory and protective functions to the skin immune system.