The role of HIV serostatus disclosure in antiretroviral medication adherence
The role of HIV serostatus disclosure in antiretroviral medication adherence
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DOI：
10.1007/s10461-006-9106-6
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发表时间：
2006-09-01
影响因子：
4.4
通讯作者：
Krieger, Daniel
中科院分区：
文献类型：
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作者：
Stirratt, Michael J.;Remien, Robert H.;Krieger, Daniel
本研究调查了HIV血清状态披露与抗逆转录病毒治疗（ART）依从性之间的关系。该研究对215名hiv血清阳性患者进行了研究，这些患者表现出较差的依从性（< 80%）和血清不一致的关系。参与者完成了关于艾滋病毒血清状态披露和缺少抗逆转录病毒药物剂量的原因的自我报告措施，以及抗逆转录病毒药物依从性的电子监测（MEMS caps）。总体而言，19%的样本报告由于担心血清状态披露而在过去两个月内遗漏了药物剂量。向他人报告更多血清状态信息的参与者表现出更高的依从率，并且在控制其他解释变量后，这种关系仍然存在。披露与依从性之间的关系不受他人对依从性的实际支持的中介作用。改善抗逆转录病毒治疗依从性的干预措施应通过向患者提供在不披露情况下保持依从性的技能，并在选择性披露方面做出知情选择，从而解决血清状态披露的作用。
This study examined the relationship between HIV serostatus disclosure and adherence to antiretroviral therapy (ART). The study was conducted with 215 HIV-seropositive patients who demonstrated poor adherence (< 80%) and who were in serodiscordant relationships. Participants completed self-report measures regarding HIV serostatus disclosure and reasons for missing ART doses, as well as electronic monitoring of ART adherence (MEMS caps). Overall, 19% of the sample reported missing medication doses in the last two months due to concerns regarding serostatus disclosure. Participants who reported greater serostatus disclosure to others demonstrated higher rates of adherence, and this relationship remained after controlling for other explanatory variables. The relationship between disclosure and adherence was not mediated by practical support for adherence from others. Interventions to improve ART adherence should address the role of serostatus disclosure by providing patients with skills to maintain adherence in contexts of non-disclosure and to make informed choices regarding selective disclosure.