Hydrophobins: multipurpose proteins.
Hydrophobins: multipurpose proteins.
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DOI：
10.1146/annurev.micro.55.1.625
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发表时间：
2001-10
影响因子：
10.5
通讯作者：
H. Wösten
中科院分区：
文献类型：
--
作者：
H. Wösten
I类和II类疏水蛋白是小的分泌性真菌蛋白，其在丝状真菌的生长和发育的广泛过程中发挥作用。例如，它们参与气生结构的形成和菌丝附着到疏水表面。疏水蛋白实现这些功能的机制是基于它们在疏水-疏水界面自组装成10 nm薄的高度两亲性膜的性质。互补研究表明，I类疏水蛋白属于一个密切相关的组的形态发生蛋白，但它们已经进化到在特定的接口功能。最近的证据表明，疏水蛋白不仅通过自组装起作用。单体疏水蛋白与细胞壁组装有关，但其潜在机制尚不清楚。此外，疏水蛋白单体可以作为毒素和诱导剂。
Class I and class II hydrophobins are small secreted fungal proteins that play a role in a broad range of processes in the growth and development of filamentous fungi. For instance, they are involved in the formation of aerial structures and in the attachment of hyphae to hydrophobic surfaces. The mechanisms by which hydrophobins fulfill these functions are based on their property to self-assemble at hydrophilic-hydrophobic interfaces into a 10 nm-thin highly amphipathic film. Complementation studies have shown that class I hydrophobins belong to a closely related group of morphogenetic proteins, but that they have evolved to function at specific interfaces. Recent evidence indicates that hydrophobins do not only function by self-assembly. Monomeric hydrophobin has been implicated in cell-wall assembly, but the underlying mechanism is not yet clear. In addition, hydrophobin monomers could act as toxins and elicitors.