Regression of rectal mucosa-associated lymphoid tissue (MALT) lymphoma after antibiotic treatments
Regression of rectal mucosa-associated lymphoid tissue (MALT) lymphoma after antibiotic treatments
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DOI：
10.1111/j.1440-1827.2010.02538.x
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发表时间：
2010-06-01
影响因子：
2.2
通讯作者：
Ohshima, Koichi
中科院分区：
文献类型：
--
作者：
Niino, Daisuke;Yamamoto, Kouhei;Ohshima, Koichi
只有少数报告描述了抗生素治疗后直肠粘膜相关淋巴组织（MALT）淋巴瘤的消退通常被发现对胃肿瘤是成功的。我们检查了八例接受抗生素治疗的直肠 MALT 淋巴瘤，以确定它们在治疗后是否消退。我们还讨论了直肠MALT淋巴瘤与MALT1基因遗传异常之间的关系。八名接受过抗生素治疗的患者在治疗开始后接受结肠镜检查。 8例中有5例（63%）内镜检查显示直肠肿瘤消失，并得到组织学证实。免疫球蛋白重链的聚合酶链反应在八个病例中的七个 (88%) 中鉴定出单克隆条带。在用荧光原位杂交 (FISH) 分析 MALT1 易位的 8 例病例中，有 2 例显示 MALT1 基因遗传异常。这些病例往往对抗生素治疗产生耐药性。需要对大量直肠 MALT 淋巴瘤进行调查和分析，以建立合适的抗生素治疗标准。
Only a few reports have described regression of rectal mucosa-associated lymphoid tissue (MALT) lymphoma after antibiotic treatment are generally found to be successful for gastric tumors. We examined eight rectal MALT lymphomas treated with antibiotic treatments to determine whether they regressed after treatment. We also discuss the relationship between rectal MALT lymphomas and MALT1 gene genetic abnormalities. Eight patients who had undergone antibiotic treatments were followed up with colonoscopy after initiation of the treatment. In five of the eight cases (63%) endoscopic examination showed that the rectal tumor had disappeared, which was confirmed histologically. Polymerase chain reaction for immunoglobulin heavy chain identified a monoclonal band in seven of eight cases (88%). Of the eight cases analyzed with fluorescence in situ hybridization (FISH) for MALT1 translocation, two demonstrated MALT1 gene genetic abnormality. These cases tended to be resistant to antibiotic treatment. Investigation and analysis of a large number of rectal MALT lymphomas are needed to establish suitable standards for antibiotic treatment.