Direct activation of guinea pig vagal afferent neurons by FMRFamide.
Direct activation of guinea pig vagal afferent neurons by FMRFamide.
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FMRFamide 直接激活豚鼠迷走神经传入神经元。
DOI：
10.1097/wnr.0b013e3283495a6e
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发表时间：
2011
期刊：
影响因子：
1.7
通讯作者：
Undem,BradleyJ
中科院分区：
文献类型：
--
作者：
Lee,Min-Goo;Park,Ji-Yong;Park,YoungKeun;Undem,BradleyJ
迷走神经包括两种不同的神经：结状神经和颈静脉神经节神经。我们测试了两条迷走神经对 FMRFamide 反应性的药理学差异。在细胞内钙测量中，结节神经对 FMRFamide 的反应概率显着高于颈神经。在膜片钳记录中，结状神经对 FMRFamide 的膜电位去极化也比颈神经多，尽管两种神经的动作电位放电概率相同。 FMRFamide 诱导的内向电流被表征为混合阳离子。这些结果表明 FMRFamide 可能充当迷走感觉神经的激活剂和调节剂，用于治疗内脏疾病的症状。
Vagus nerve comprises two distinct kinds of nerves, nodose and jugular ganglionic nerves. We tested pharmacological difference between two vagal nerves in the responsiveness to FMRFamide. The response probability to FMRFamide was significantly higher in nodose than jugular nerves in intracellular calcium measurement. Nodose nerves also depolarized membrane potential to FMRFamide more than jugular nerves did, in patch-clamp recording, although the probability of action potential discharge was same in both nerves. The inward current induced by FMRFamide was characterized as mixed cations. These results suggest that FMRFamide may act as an activator and modulator of vagal sensory nerves for treating symptoms in visceral diseases.