Induction of fertile oestrus in dioestrous bitches by prostaglandin F2α and a GnRH-agonist
Induction of fertile oestrus in dioestrous bitches by prostaglandin F2α and a GnRH-agonist
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前列腺素 F2α 和 GnRH 激动剂诱导间情母犬可育发情
DOI：
10.1136/vr.d1183
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Inaba T
中科院分区：
文献类型：
--
作者：
Ohmura M;Torii R;Hatoya S;Sugiura K;Tamada H;Kawate N;Takahashi M;Sawada T;Inaba T
组母犬数量发情间期（天）发情前期（天）发情持续时间（天）妊娠（天）妊娠率（%）窝仔数对照组13-209（9）a 7. 8（0.7）a 8.0（0.3）62.1（0.8）13/13（100）4.0（0.7）PG 15 + LA 35 * 6 5 61（2）B 3.0（0.4）B 7.3（0.9）-0/5（0）-PG 15 + LA 50 [匕首] 7 7 76（2）B 5.2（0.8）a 8.0（0.9）62.0（1.5）5/7（71）2.6（1.0）PG 30 + LA 50 [双刃剑] 6 6 97（5）B 6.7（0.7）a 8.3（0.9）63.3（1.2）5/6（83）3.0（1.7）从排卵后15天开始，连续4天每天两次皮下注射250 µg/kg PGF 2 β ±，然后在PGF 2 β ±预处理后35天单次皮下注射100 µg/kg醋酸亮丙瑞林，随后在诱导发情开始时单次肌内注射3 µg/kg Fertirelin母犬从排卵后15天开始接受PGF 2 β ±，然后在PGF 2 β ±预处理后50天接受醋酸亮丙瑞林，随后在诱导发情开始时给予Fertirelin，如上所述，母犬从排卵后30天开始接受PGF 2 β ±，然后在PGF 2 β ±预处理后50天接受醋酸亮丙瑞林，随后在诱导发情开始时给予Fertirelin，如上所述，具有不同上标的值显著不同（P< 0.01）该简短交流描述了一项研究，旨在确定PGF 2 β ±和醋酸亮丙瑞林联合用药是否能可靠地诱导间情期母犬的可育发情。[...]这些结果表明给予PGF 2 β 1和醋酸亮丙瑞林的组合可用于控制诱导间情期母犬的可育发情。
Group Number of bitches Number of bitches responding Interoestrous interval (days) Pro-oestrus (days) Length of oestrus (days) Gestation (days) Pregnancy rate (%) Litter size Control 13-209 (9) a 7.8 (0.7) a 8.0 (0.3) 62.1 (0.8) 13/13 (100) 4.0 (0.7) PG15+ LA35* 6 5 61 (2) b 3.0 (0.4) b 7.3 (0.9)-0/5 (0)-PG15+ LA50 [dagger] 7 7 76 (2) b 5.2 (0.8) a 8.0 (0.9) 62.0 (1.5) 5/7 (71) 2.6 (1.0) PG30+ LA50 [double dagger] 6 6 97 (5) b 6.7 (0.7) a 8.3 (0.9) 63.3 (1.2) 5/6 (83) 3.0 (1.7) Bitches were treated subcutaneously with 250 µg/kg PGF2αtwice daily for four consecutive days from 15 days after ovulation, then a single subcutaneous injection of 100 µg/kg leuprolide acetate 35 days after PGF2αpretreatment, followed by a single injection of 3 µg/kg fertirelin intramuscularly at the onset of induced oestrus Bitches received PGF2αfrom 15 days after ovulation, then leuprolide acetate 50 days after PGF2αpretreatment, followed by fertirelin at the onset of induced oestrus, as described above Bitches received PGF2αfrom 30 days after ovulation, then leuprolide acetate 50 days after PGF2αpretreatment, followed by fertirelin at the onset of induced oestrus, as described above Values with different superscripts differ significantly (P< 0.01) This short communication describes a study to determine whether a combination of PGF2αand leuprolide acetate can reliably induce fertile oestrus in dioestrous bitches.[...] these results indicate that administration of a combination of PGF2αand leuprolide acetate is useful in controlling the induction of fertile oestrus in dioestrous bitches.