The inconvenience of convenience cohorts: rhabdomyosarcoma and the PAX-FOXO1 biomarker.
The inconvenience of convenience cohorts: rhabdomyosarcoma and the PAX-FOXO1 biomarker.
复制标题
便利队列的不便：横纹肌肉瘤和 PAX-FOXO1 生物标志物。
DOI：
10.1158/1055-9965.epi-12-0207
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
Hawkins,DouglasS
中科院分区：
文献类型：
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作者：
Rosenberg,AbbyR;Skapek,StephenX;Hawkins,DouglasS
“便利队列”包括被认为代表一般人群的个人，但选择他们是因为他们很容易被评估，而不是随机的。因此，这些方法会受到偏见的影响，可能会产生误导。便捷队列被用于研究横纹肌肉瘤（最常见的儿童肉瘤）中pax3or pax7和foxo1基因染色体易位的预后意义。然而，评估pax - foxo1易位作用的回顾性研究得出了不一致的结果。本综述重点介绍了pax - foxo1生物标志物的几项临床相关研究的结果，并说明了使用这些方法得出临床结论的挑战。癌症流行病学生物标志物；21 (7);1012 - 8。AACR©2012。
“Convenience cohorts” comprise individuals thought to represent the general population, but chosen because they are readily available for evaluation, rather than at random. As such, these methods are subject to bias and may be misleading. Convenience cohorts have been used to investigate the prognostic significance of chromosomal translocations between thePAX3orPAX7and theFOXO1genes in rhabdomyosarcoma, the most common pediatric sarcoma. However, retrospective studies assessing the role ofPAX-FOXO1translocations have yielded inconsistent results. This review highlights the findings from several clinical correlation studies of thePAX-FOXO1biomarker and illustrates the challenges of using such methods to draw clinical conclusions.Cancer Epidemiol Biomarkers Prev; 21(7); 1012–8. ©2012 AACR.