Involvement of NMDA receptors in the ventrolateral striatum of rats in apomorphine-induced jaw movements
Involvement of NMDA receptors in the ventrolateral striatum of rats in apomorphine-induced jaw movements
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DOI：
10.1016/j.brainres.2010.01.068
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发表时间：
2010-03-31
期刊：
影响因子：
2.9
通讯作者：
Waddington, John L.
中科院分区：
文献类型：
--
作者：
Fujita, Satoshi;Kiguchi, Motori;Waddington, John L.
使用磁传感器系统结合脑内微量注射药物，研究了腹外侧纹状体中 NMDA 受体调节多巴胺受体介导的下颌运动的作用。阿扑吗啡（1 mg/kg，静脉注射）诱导重复性下颌运动，通过将 NMDA 受体激动剂 NMDA（双侧 0.1 和 1 μg/0.2 μl）双侧显微注射到腹外侧纹状体中，该运动以剂量依赖性方式减少。通过双侧显微注射 NMDA 受体拮抗剂 D-APV（0.01 和 0.1 μg）或 MK-801（0.5 和 5 μg），阿朴吗啡诱导的重复下颌运动也以剂量依赖性方式减少。与MK-801(0.5μg)共同给药可降低NMDA(1μg)的抑制作用。在没有阿扑吗啡的情况下，将药物显微注射到腹外侧纹状体中不会影响下颌运动。这些结果表明，腹外侧纹状体中的 NMDA 受体在多巴胺受体介导的下颌运动的表达中发挥重要的调节作用。然而，NMDA 和 NMDA 拮抗剂的类似作用与之前的矛盾发现相呼应，表明多巴胺和 NMDA 受体之间的相互作用是复杂且多方面的。细胞机制可能涉及 NMDA 激动和拮抗对多巴胺 D1 样受体和 D2 样受体的不同作用，并且可能涉及相关的 GABA 能过程。 (C) 2010 Elsevier B.V. 保留所有权利。
The role of NMDA receptors in the ventrolateral striatum to modulate dopamine receptor-mediated jaw movements was investigated in freely moving rats, using a magnetic sensor system combined with intracerebral microinjection of drugs. Apomorphine (1 mg/kg i.v.) induced repetitive jaw movements that were reduced, in a dose-dependent manner, by bilateral microinjections of the NMDA receptor agonist NMDA (0.1 and 1 mu g/0.2 mu l bilaterally) into the ventrolateral striatum. Apomorphine-induced repetitive jaw movements were also reduced, in a dose-dependent manner, by bilateral microinjections of the NMDA receptor antagonists D-APV (0.01 and 0.1 mu g) or MK-801 (0.5 and 5 mu g). The inhibitory effect of NMDA (1 mu g) was reduced by co-administration of MK-801 (0.5 mu g). Microinjections of drugs into the ventrolateral striatum in the absence of apomorphine did not affect jaw movements. These results suggest that NMDA receptors in the ventrolateral striatum play an important modulatory role in the expression of dopamine receptor-mediated jaw movements. However, similar effects of NMDA and NMDA antagonists echo previous paradoxical findings and indicate that interactions between dopamine and NMDA receptors are complex and multifaceted. Cellular mechanism(s) may involve differential effects of NMDA agonism and antagonism on dopamine D1-like vs D2-like receptors and, possibly, on related GABAergic processes. (C) 2010 Elsevier B.V. All rights reserved.