The evaluation of the radioprotective effect of Triphala (an ayurvedic rejuvenating drug) in the mice exposed to γ-radiation
The evaluation of the radioprotective effect of Triphala (an ayurvedic rejuvenating drug) in the mice exposed to γ-radiation
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DOI：
10.1078/0944-7113-00095
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发表时间：
2002-03-01
期刊：
影响因子：
7.9
通讯作者：
Kamath, MS
中科院分区：
文献类型：
--
作者：
Jagetia, GC;Baliga, MS;Kamath, MS
本文研究了阿育吠陀草药Triphala水提物0、5、6.25、10、12.5、20、25、40、50和80 mg/kg体重对10Gy射线照射小鼠辐射致死率的影响。与未经药物治疗的对照组相比，照射前连续5天给予不同剂量的Triphala治疗推迟了小鼠的死亡率，并减少了放射病的症状。观察到对胃肠道(胃肠道)死亡的最高保护作用是12.5毫克/公斤的Triphala，据报道，在照射后10天内存活人数最多。白藜芦醇10 mg/kg ip。提供了最好的保护，与其他剂量的Triphala相比，该组在照射后30天的幸存者人数最多。毒性研究表明，在240 mg/kg剂量下，Triphala是无毒的，没有观察到药物引起的死亡。LD50剂量ip。白藜芦醇的剂量为280 mg/kg，是一种良好的辐射防护剂，其最佳防护剂量为LD50的1/28。
The effect of 0, 5, 6.25, 10, 12.5, 20, 25, 40, 50 and 80 mg/kg b. wt. of aqueous extract of triphala (an Ayurvedic herbal medicine) administrered intraperitoneally was studied on the radiation-induced mortality in mice exposed to 10 Gy of gamma-radiation. Treatment of mice with different doses of triphala consecutively for five days before irradiation delayed the onset of mortality and reduced the symptoms of radiation sickness when compared with the non-drug treated irradiated controls. The highest protection against GI (gastrointestinal) death was observed for 12.5 mg/kg triphala, where a highest number of survivors were reported up to 10 days post-irradiation. While 10 mg/kg triphala i.p. provided the best protection as evidenced by the highest number of survivors after 30 days post-irradiation in this group when compared with the other doses of triphala. Toxicity study showed that triphala was non-toxic up to a dose of 240 mg/kg, where no drug-induced mortality was observed. The LD50 dose i.p. of triphala was found to be 280 mg/kg b. wt. Our study demonstrates the ability of triphala as a good radioprotective agent and the optimum protective dose of triphala was 1/28 of its LD50 dose.