Acromelic acid is a much more potent excitant than kainic acid or domoic acid in the isolated rat spinal cord
Acromelic acid is a much more potent excitant than kainic acid or domoic acid in the isolated rat spinal cord
复制标题
在离体大鼠脊髓中，肢端甲酸是比红藻氨酸或软骨藻酸更有效的兴奋剂
DOI：
10.1016/0006-8993(88)90456-8
复制
发表时间：
1988
期刊：
影响因子：
2.9
通讯作者：
H. Shinozaki
中科院分区：
文献类型：
--
作者：
M. Ishida;H. Shinozaki
研究了丙烯酸在离体新生大鼠脊髓中的兴奋作用。在灌注液中加入试验化合物，从细胞外记录腹根的反应。丙烯酸引起的去极化反应呈剂量依赖性，且丙烯酸的去极化活性优于其他类碱，如海因酸盐和草酸盐。NMDA拮抗剂对丙烯酸诱导的去极化无明显影响。在脊椎动物和无脊椎动物中，丙烯酸被证明是最有效的兴奋性氨基酸激动剂之一。
Excitatory actions of acromelic acid were investigated in the isolated newborn rat spinal cord. Test compounds were added to the perfusing fluid and the responses were recorded from the ventral root extracellularly. Acromelic acid caused a depolarizing response in a dose-dependent manner and the depolarizing activity of acromelic acid was superior to that of other kainoids such as kainate and domoate. The depolarization induced by acromelate was not affected by NMDA antagonists at all. Acromelic acid was proved to be one of the most potent agonists of excitatory amino acids in both vertebrates and invertibrates.