From In Situ to In Vivo: An In Situ Click-Chemistry-Derived Carbonic Anhydrase II Imaging Agent for Positron Emission Tomography
From In Situ to In Vivo: An In Situ Click-Chemistry-Derived Carbonic Anhydrase II Imaging Agent for Positron Emission Tomography
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DOI：
10.1002/cmdc.201200466
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发表时间：
2013-01-01
期刊：
影响因子：
3.4
通讯作者：
Kolb, Hartmuth C.
中科院分区：
文献类型：
--
作者：
Mocharla, Vani P.;Walsh, Joseph C.;Kolb, Hartmuth C.
CA II makes a good PET: Discovering positron emission tomography (PET) probes with high target affinities is challenging. PET probe discovery using in situ click chemistry uses (19) F-bearing fragments as (18) F surrogates. This ensures that the lead hits and PET probes have equivalent chemical or biological characteristics, making PET probe discovery predictable and reliable.
