Emotional responses associated with self-face processing in individuals with autism spectrum disorders : An fMRI study
Emotional responses associated with self-face processing in individuals with autism spectrum disorders : An fMRI study
复制标题
自闭症谱系障碍患者与自我面部处理相关的情绪反应：一项功能磁共振成像研究
DOI：
10.1080/17470919.2011.598945
复制
发表时间：
2012
影响因子：
2
通讯作者：
et al
中科院分区：
文献类型：
--
作者：
Morita;T.;Kosaka;H.;Saito;D.;Ishitobi;M.;Munesue;T.;Itakura;S.;et al
患有自闭症谱系障碍 (ASD) 的个体对自我面孔处理的情绪反应受损，但潜在的神经基础尚不清楚。我们利用功能性磁共振成像技术，调查了 15 名高功能自闭症患者和 15 名对照者对自己面部图像和他人面部照片的上镜性进行评分时的大脑活动。对照显示，上镜性评级与自拍图像引起的尴尬程度之间存在很强的相关性；这种相关性在自闭症谱系障碍个体中较弱，表明自我面部图像的认知评估与情绪反应之间存在脱钩。患有自闭症谱系障碍的个体在后扣带皮层（PCC）中表现出相对较低的自我相关活动，这与特定的自闭症特征有关。右侧岛叶（IC）和外侧眶额皮质中的尴尬等级对活动的调节存在显着的群体差异。 ASD 组右侧 IC 的任务相关活动较低。自我面部图像右侧 IC 的活动减少与自我面部图像的认知评估和情绪反应之间的弱耦合有关。 PCC负责自我参照处理，IC则在情感体验中发挥作用。这些区域的功能障碍可能导致自闭症谱系障碍者缺乏对自我反思的自我意识行为。
Individuals with autism spectrum disorders (ASD) show impaired emotional responses to self-face processing, but the underlying neural bases are unclear. Using functional magnetic resonance imaging, we investigated brain activity when 15 individuals with high-functioning ASD and 15 controls rated the photogenicity of self-face images and photographs of others' faces. Controls showed a strong correlation between photogenicity ratings and extent of embarrassment evoked by self-face images; this correlation was weaker among ASD individuals, indicating a decoupling between the cognitive evaluation of self-face images and emotional responses. Individuals with ASD demonstrated relatively low self-related activity in the posterior cingulate cortex (PCC), which was related to specific autistic traits. There were significant group differences in the modulation of activity by embarrassment ratings in the right insular (IC) and lateral orbitofrontal cortices. Task-related activity in the right IC was lower in the ASD group. The reduced activity in the right IC for self-face images was associated with weak coupling between cognitive evaluation and emotional responses to self-face images. The PCC is responsible for self-referential processing, and the IC plays a role in emotional experience. Dysfunction in these areas could contribute to the lack of self-conscious behaviors in response to self-reflection in ASD individuals.