Difference in central projection of primary afferents innervating facial and intraoral structures in the rat
Difference in central projection of primary afferents innervating facial and intraoral structures in the rat
复制标题
大鼠中支配面部和口腔内结构的初级传入神经的中心投影的差异
DOI：
10.1016/0014-4886(91)90099-x
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发表时间：
1991
影响因子：
5.3
通讯作者：
Y. Shigenaga
中科院分区：
文献类型：
--
作者：
M. Takemura;T. Sugimoto;Y. Shigenaga
用辣根过氧化物酶-麦胚凝集素结合物的跨神经节转运研究了支配面部和口内结构的初级传入神经元的中枢投射。所检查的初级神经元支配的面部结构是那些包括额和颧面神经和那些支配角膜，而初级神经元支配的口内结构包括那些支配下颌切牙和磨牙牙髓和那些包括腭神经。支配面部结构的初级传入纤维投射到三叉神经主核、口核和极间亚核的外侧或腹侧部分，并穿过I层至V层投射到头侧颈脊髓背角，其中更大比例的传入纤维直接投射到脊髓背角。支配口内结构的初级传入终止于三叉神经主核、口核和极间亚核的背内侧亚核，以及内侧延髓背角的I、II和V层，其中更密集的投射分布于吻侧亚核。除上述脑干三叉神经感觉核复合体外，它们还投射到三叉上核、孤束尾侧核和三叉旁核。这些观察结果同意以前报道的数据，三叉神经的中央投影是以不同的方式组织的面部和口内结构。此外，目前的研究结果与我们以前的研究澄清，从面部皮肤的初级传入神经的中央投影组织在一个明确的躯体位置的方式，并从口内结构的初级传入神经的终端领域广泛重叠在脑干三叉神经核复合体，特别是在其喙部细分。三叉神经伤害性感受的中枢机制进行了讨论，特别是相对于它的面部和口内结构之间的差异。
Transganglionic transport of horseradish peroxidase-wheat germ agglutinin conjugate was used to study the central projection of primary afferent neurons innervating facial and intraoral structures. The examined primary neurons innervating the facial structures were those comprising the frontal and zygomaticofacial nerves and those innervating the cornea, while the primary neurons innervating the intraoral structures included those innervating the mandibular incisor and molar tooth pulps and those comprising the palatine nerve. The primary afferents innervating the facial structures project to the lateral or ventral parts of the trigeminal principal, oral and interpolar subnuclei, and to the rostral cervical spinal dorsal horn across laminae I through V, with a greater proportion being directed to the spinal dorsal horn. The primary afferents innervating the intraoral structures terminate in the dorsomedial subdivisions of the trigeminal principal, oral and interpolar subnuclei, and in laminae I, II, and V of the medial medullary dorsal horn, with a much denser projection being distributed to the rostral subnuclei. In addition to the above brain stem trigeminal sensory nuclear complex, they project to the supratrigeminal nucleus, caudal solitary tract nucleus, and paratrigeminal nucleus. These observations agree with previously reported data that the central projection of trigeminal nerve is organized in different manners for the facial and intraoral structures. Furthermore, the present findings in conjunction with our previous studies clarify that the central projection of primary afferents from the facial skin is organized in a clear somatotopic fashion and that the terminal fields of primary afferents from the intraoral structures extensively overlap in the brain stem trigeminal nuclear complex particularly in its rostral subdivisions. The central mechanism of trigeminal nociception is discussed with particular respect to its difference between the facial and intraoral structures.