Drug-drug interactions in the elderly
Drug-drug interactions in the elderly
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DOI：
10.1345/aph.1a484
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发表时间：
2002-11-01
影响因子：
2.9
通讯作者：
Bernsten, CB
中科院分区：
文献类型：
--
作者：
Björkman, IK;Fastbom, J;Bernsten, CB
目的：为了检测潜在的药物相互作用（DDI）的频率在门诊组的老年人在6个欧洲国家，以及描述countries.DATA SourcesandMETHODS之间的差异：药物使用数据收集1601老年人生活在6个欧洲国家。研究人群参加了一项为期18个月的对照干预研究，调查药学服务的影响。潜在的DDI进行了研究，使用计算机检测program.RESULTS：老年人口平均每人使用7.0种药物，46%的至少有1种药物组合可能导致DDI。平均而言，每人有0.83个潜在的DDI。根据瑞典相互作用分类系统，近10%的潜在DDI被分类为应避免，但其中近三分之一仅适用于易感患者。潜在DDI导致的亚治疗效应风险与不良反应风险一样常见。此外，我们发现潜在的DDI的频率和类型之间的差异countries.CONCLUSIONS：潜在的DDI是常见的老年人使用许多药物，是一个正常的药物治疗方案的一部分。某些组合可能会产生负面影响;必须更多地关注检测和监测使用此类组合的患者。由于发现各国之间潜在的DDI存在差异，因此需要在进一步研究中探讨这种差异的原因。
OBJECTIVE: To detect the frequency of potential drug-drug interactions (DDIs) in an outpatient group of elderly people in 6 European countries, as well as to describe differences among countries.DATA SOURCES AND METHODS: Drug use data were collected from 1601 elderly persons living in 6 European countries. The study population participated in a controlled intervention study over 18 months investigating the impact of pharmaceutical care. Potential DDIs were studied using a computerized detection program.RESULTS: The elderly population used on average 7.0 drugs per person; 46% had at least 1 drug combination possibly leading to a DDI. On average, there were 0.83 potential DDIs per person. Almost 10% of the potential DDIs were classified to be avoided according to the Swedish interaction classification system, but nearly one-third of them were to be avoided only for predisposed patients. The risk of subtherapeutic effect as a result of a potential DDI was as common as the risk of adverse reactions. Furthermore, we found differences in the frequency and type of potential DDIs among the countries.CONCLUSIONS: Potential DDIs are common in elderly people using many drugs and are part of a normal drug regimen. Some combinations are likely to have negative effects; more attention must be focused on detecting and monitoring patients using such combinations. As differences in potential DDIs among countries were found, the reasons for this variability need to be explored in further studies.