Predictors for incidence and remission of NAFLD in the general population during a seven-year prospective follow-up
Predictors for incidence and remission of NAFLD in the general population during a seven-year prospective follow-up
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DOI：
10.1016/j.jhep.2011.12.011
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发表时间：
2012-01-01
影响因子：
25.7
通讯作者：
Oren, Ran
中科院分区：
文献类型：
--
作者：
Zelber-Sagi, Shira;Lotan, Roni;Oren, Ran
背景与目的：关于非酒精性脂肪性肝病（NAFLD）的发病率和缓解率以及预测因素的数据很少。本研究的目的是在评估非酒精性脂肪肝的流行病学在前瞻性随访的个人抽样从一般population.Methods：评估代谢参数和超声检查证据的非酒精性脂肪肝进行了213例，没有已知的肝脏疾病或酗酒史。评估进行了基线和7年后，由相同的protocols.Results期间：147例患者谁没有NAFLD在基线，28（19%）被发现有NAFLD在7年的后续行动。基线BMI、HOMA评分、血胆固醇、甘油三酯、瘦素水平和体重增加（5.8 ± 6.1 vs 1.4 ± 5.5 kg，p
Background & Aims: Data on the incidence and remission rates of non-alcoholic fatty liver disease (NAFLD) as well as predictive factors are scant. This study aims at evaluating NAFLD's epidemiology in prospective follow-up of individuals sampled from the general population.Methods: Evaluation of metabolic parameters and ultrasono-graphic evidence of NAFLD was performed in 213 subjects, with no known liver disease or history of alcohol abuse. The evaluation was performed at baseline and after a 7-year period by identical protocols.Results: Of the 147 patients who did not have NAFLD at baseline, 28 (19%) were found to have NAFLD at a 7-year follow-up. Baseline BMI, HOMA score, blood cholesterol, triglycerides, leptin levels, and weight gain (5.8 +/- 6.1 vs. 1.4 +/- 5.5 kg, p