Impact of acute exercise intensity on pulsatile growth hormone release in men.
Impact of acute exercise intensity on pulsatile growth hormone release in men.
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急性运动强度对男性脉动生长激素释放的影响。
DOI：
10.1152/jappl.1999.87.2.498
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Weltman,A
中科院分区：
文献类型：
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作者：
Pritzlaff,CJ;Wideman,L;Weltman,JY;Abbott,RD;Gutgesell,ME;Hartman,ML;Veldhuis,JD;Weltman,A
为了研究运动强度对生长激素 (GH) 释放的影响，10 名男性受试者在 6 个随机顺序的场合进行了测试 [1 个对照条件 (C)，5 个运动条件 (Ex)]。血清 GH 浓度是在 0700 至 0900（基线）以及 0900 至 1300（运动+恢复）之间每隔 10 分钟采集的样本进行测量。通过梯形重建计算综合 GH 浓度 (IGHC)。在Ex期间，受试者以以下强度之一运动30分钟（0900-0930）[标准化为乳酸阈值（LT）]：LT与休息之间差异的25％和75％（分别为0.25LT和0.75LT），在LT时，以及LT与峰值之间差异的25％和75％（分别为1.25LT和1.75LT）。基线 IGHC 条件之间没有观察到差异。运动+恢复 IGHC（平均值 ± SE：C = 250 ± 60；0.25LT = 203 ± 69；0.75LT = 448 ± 125；LT = 452 ± 119；1.25LT = 512 ± 121；1.75LT = 713 ± 115 µg ⋅ l−1⋅ min−1）增加与运动强度的增加呈线性关系（P<0.05）。反卷积分析显示，运动强度的增加导致每次脉冲分泌的 GH 质量和 GH 生成率呈线性增加[生成率从 16.5 ± 4.5 (C) 增加到 32.1 ± 5.2 μg·分布体积−1·min−1(1.75LT)，P< 0.05]，而 GH 脉冲频率或消除半衰期没有变化。我们得出的结论是，年轻男性的 GH 分泌反应与运动强度呈线性剂量反应模式相关。
To investigate the effects of exercise intensity on growth hormone (GH) release, 10 male subjects were tested on 6 randomly ordered occasions [1 control condition (C), 5 exercise conditions (Ex)]. Serum GH concentrations were measured in samples obtained at 10-min intervals between 0700 and 0900 (baseline) and 0900 and 1300 (exercise+ recovery). Integrated GH concentrations (IGHC) were calculated by trapezoidal reconstruction. During Ex subjects exercised for 30 min (0900–0930) at one of the following intensities [normalized to the lactate threshold (LT)]: 25 and 75% of the difference between LT and rest (0.25LT and 0.75LT, respectively), at LT, and at 25 and 75% of the difference between LT and peak (1.25LT and 1.75LT, respectively). No differences were observed among conditions for baseline IGHC. Exercise+recovery IGHC (mean ± SE: C = 250 ± 60; 0.25LT = 203 ± 69; 0.75LT = 448 ± 125; LT = 452 ± 119; 1.25LT = 512 ± 121; 1.75LT = 713 ± 115 μg ⋅ l−1⋅ min−1) increased linearly with increasing exercise intensity (P< 0.05). Deconvolution analysis revealed that increasing exercise intensity resulted in a linear increase in the mass of GH secreted per pulse and GH production rate [production rate increased from 16.5 ± 4.5 (C) to 32.1 ± 5.2 μg ⋅ distribution volume−1⋅ min−1(1.75LT),P< 0.05], with no changes in GH pulse frequency or half-life of elimination. We conclude that the GH secretory response to exercise is related to exercise intensity in a linear dose-response pattern in young men.