Functions of γC cytokines in immune homeostasis: current and potential clinical applications.
Functions of γC cytokines in immune homeostasis: current and potential clinical applications.
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DOI：
10.1016/j.clim.2009.03.512
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发表时间：
2009-08
期刊：
影响因子：
--
通讯作者：
Schluns KS
中科院分区：
文献类型：
--
作者：
Overwijk WW;Schluns KS
通过含有共同γ（γC）链受体亚基的受体复合物发出信号的细胞因子是淋巴细胞稳态的中心调节因子。在这篇综述中，我们讨论了四种主要的γC细胞因子，已被证明在免疫治疗中具有活性或潜力：IL-2，IL-7，IL-15和IL-21。它们对特定淋巴细胞群体的共同和独特的活性表明了治疗应用，例如增强淋巴细胞重建，扩增肿瘤和病原体特异性淋巴细胞，以及优化疫苗。由于单个淋巴细胞亚群的反应性在不同情况下（如淋巴细胞减少症和主动免疫反应）不同，因此了解含γ C受体表达的动态对于决定如何实现最理想的效果非常重要。目前对γC细胞因子生物学的理解表明了几种临床应用，包括直接给药或用于产生过继转移的淋巴细胞，增加其内源性产生，以及通过与特异性抗体或其特异性受体α亚基形成复合物来增强其活性。总的来说，γC细胞因子具有很大的潜力，通过其单独或组合的靶向使用，成为临床干预的一个组成部分，具有增强的疗效和降低的毒性。
Cytokines that signal through receptor complexes containing the common γ (γC) chain receptor subunit are central regulators of lymphocyte homeostasis. In this review, we discuss the four major γC cytokines that have proven activity in or potential for immunotherapy: IL-2, IL-7, IL-15 and IL-21. Their shared and unique activities on specific lymphocyte populations suggest therapeutic applications such as enhancing lymphocyte reconstitution, expanding tumor and pathogen-specific lymphocytes, and optimizing vaccines. Because the responsiveness of individual lymphocyte subsets varies under different situations such as lymphopenia and active immune responses, understanding the dynamics of γC-containing receptor expression is important in deciding how to achieve the most desired effect. Current understanding of γC cytokine biology suggests several clinical applications, including their direct administration or use in generation of lymphocytes for adoptive transfer, increasing their endogenous production, and potentiating their activity by complex formation with specific antibodies or their specific receptor-α subunits. Overall, γC cytokines have great potential, through their targeted use alone or in combination, to be an integral part of clinical interventions with enhanced efficacy and decreased toxicity.
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