Self-assembling peptide polyelectrolyte β-sheet complexes form nematic hydrogels
Self-assembling peptide polyelectrolyte β-sheet complexes form nematic hydrogels
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DOI：
10.1002/anie.200352207
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发表时间：
2003-01-01
影响因子：
16.6
通讯作者：
Strong, AE
中科院分区：
文献类型：
--
作者：
Aggeli, A;Bell, M;Strong, AE
An emergent activity is exploration of the prospect for exploiting proteinlike self-assembly as a route to novel soft solidlike materials, with the objective of being able to incorporate proteinlike responsivity into their nanostructure.[1–5] Our approach has been to exploit the intrinsic onedimensional self-assembling propensity of peptides to form cross-β-structures.[2–4] A hierarchy of structures: helical tapes (single-molecule thick), twisted ribbons (double tapes), fibrils (twisted stacks of ribbons), and fibers (entwined fibrils) are formed successively with increasing concentration in water.[2, 3] The fibrils are semirigid and can form nematic fluids at concentrations of about 0.001 v/v, whilst fiber formation occurs at higher concentrations and gives rise to networks comprised of fibrils linked at fiberlike junctions that create nematic hydrogels.[3] This behavior has been shown to stem from the chirality of the peptide molecule, which in turn originates from the intrinsic chirality of the constituent amino acids (l in the case of naturally occurring ones). Another ubiquitous property of peptides is their ability to become electrostatically charged in response to changes in pH values.
