Base-mediated decomposition of amide-substituted furfuryl tosylhydrazones: synthesis and cytotoxic activities of enynyl-ketoamides.
Base-mediated decomposition of amide-substituted furfuryl tosylhydrazones: synthesis and cytotoxic activities of enynyl-ketoamides.
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DOI：
10.1021/jo502328j
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发表时间：
2015-02
期刊：
影响因子：
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通讯作者：
F. Ji;Hui Peng;Xiaoting Zhang;Wenhua Lu;Shubin Liu;Huanfeng Jiang;Bo Liu;Biaolin Yin
中科院分区：
文献类型：
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作者：
F. Ji;Hui Peng;Xiaoting Zhang;Wenhua Lu;Shubin Liu;Huanfeng Jiang;Bo Liu;Biaolin Yin
酰胺基取代的呋喃对甲苯磺酰肼的碱解反应为合成新型的多官能团烯芳基酮酰胺提供了可行的途径。此外，具有稳定呋喃环的呋喃对甲苯磺酰肼发生了有趣的对甲苯磺基迁移，形成了具有潜在合成应用的砜类化合物。所合成的一些烯芳基酮酰胺类化合物对人肿瘤细胞具有良好的细胞毒作用。
Base-mediated decomposition of amide-substituted furfuryl tosylhydrazones afforded practical access to novel multifunctionalized enynyl-ketoamides. In addition, furfuryl tosylhydrazones with stable furan rings underwent an interesting tosyl-group migration to form sulfones, which have potential synthetic applications. Some of the obtained enynyl-ketoamides demonstrated good cytotoxicities against human tumor cell lines.