Muscle symptoms associated with statins:: A series of twenty patients
Muscle symptoms associated with statins:: A series of twenty patients
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DOI：
10.1111/j.1742-7843.2006.pto_193.x
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发表时间：
2006-01-01
影响因子：
3.1
通讯作者：
Kivistö, KT
中科院分区：
文献类型：
--
作者：
Soininen, K;Niemi, M;Kivistö, KT
本研究的目的是检查无明显诱发因素的患者中他汀类药物引起的肌痛的临床特征。在2003年1月至2004年7月期间，在库桑科斯基地区医院及其集水区（人口约100，000）的患者中，前瞻性地确定了报告他汀类药物使用期间肌肉主诉限制日常功能的患者。20例肌肉投诉可能归因于使用他汀类药物的患者被纳入本系列。无严重肌病或横纹肌溶解病例，观察到的最高肌酸激酶值仅约为1900 U/l。在18例可评价肌酸激酶水平的患者中，5例（28%）未显示肌酸激酶升高，6例（33%）仅显示轻微升高。停用他汀类药物后，13例肌酸激酶值升高和肌肉不适的患者中有11例出现症状缓解和肌酸激酶正常化。他汀类药物可能会引起临床上重要的肌肉症状，而不会引起明显的肌酸激酶升高。
The aim of this study was to examine the clinical profile of statin-induced myalgia in patients with no apparent predisposing factors. Patients who reported muscle complaints that limited daily functioning during statin use were prospectively identified among the patients of Kuusankoski District Hospital and its catchment area, a population of about 100,000, between January 2003 and July 2004. Twenty patients in whom the muscle complaints were probably attributable to the use of a statin were included in this series. There were no cases of severe myopathy or rhabdomyolysis, and the highest creatine kinase value observed was only about 1900 U/l. Of the 18 patients that were evaluable for creatine kinase level, 5 (28%) did not exhibit elevation of creatine kinase and 6 (33%) showed a minor increase only. Following discontinuation of the statin, resolution of symptoms and normalisation of creatine kinase occurred in 11 of the 13 patients with elevated creatine kinase value as well as muscle complaints. Statins may cause clinically important muscle symptoms without inducing a marked creatine kinase elevation.