Morphological evidence for two types of idiopathic 'Sertoli-cell-only' syndrome.
Morphological evidence for two types of idiopathic 'Sertoli-cell-only' syndrome.
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两种特发性“仅支持细胞”综合征的形态学证据。
DOI：
10.1111/j.1365-2605.1991.tb01073.x
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发表时间：
1991
影响因子：
--
通讯作者：
S. Hatakeyama
中科院分区：
文献类型：
--
作者：
T. Terada;S. Hatakeyama
根据组织学和免疫组化结果，将41例诊断为特发性仅支持细胞综合征的患者的睾丸标本活检分为两种类型，A型和B型。A型38例，曲细精管直径小，管壁透明化，但含有正常成人型支持细胞。另外3例被归类为B型的标本显示无曲细精管壁透明化，其支持细胞的波形蛋白分布局限于亚核细胞质中，并具有假复层衬里，特征类似于胎儿支持细胞的外观。在一个病人的睾丸腺瘤，比较研究相同的睾丸照射前后进行。由此判断，生殖细胞群的青春期后耗竭被认为是A型中观察到的小管萎缩的原因。B型睾丸虽然数量少，但其特征在于与A型睾丸不同的形态，但其发病机制尚不清楚。
Biopsies of testicular specimens taken from 41 patients that were diagnosed as having idiopathic Sertoli-cell-only syndrome were classified into two types, A and B, on the basis of histological and immunohistochemical findings. Thirty eight specimens that were classified as type A exhibited seminiferous tubules of small diameter and with tubular wall hyalinization, but containing normal adult type Sertoli cells. The other three specimens that were classified as type B showed no seminiferous tubular wall hyalinization, and their Sertoli cells had vimentin distribution localized in the subnuclear cytoplasm and had a pseudostratified lining, features resembling the appearance of fetal Sertoli cells. In one patient with a seminoma, a comparative study of the same testis prior to and post-irradiation was undertaken. Judging from this, postpubertal depletion of the germ cell population was considered to be responsible for the tubular atrophy observed in type A. Type B testes, though small in number, were characterized by a morphology distinct from the type A, but their pathogenesis remains unknown.