CISPLATIN INDUCED NEUROPATHY - CENTRAL, PERIPHERAL AND AUTONOMIC NERVE INVOLVEMENT
CISPLATIN INDUCED NEUROPATHY - CENTRAL, PERIPHERAL AND AUTONOMIC NERVE INVOLVEMENT
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DOI：
10.1007/bf02341156
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发表时间：
1990-12-01
影响因子：
3.9
通讯作者：
VANDERSANDE, JJ
中科院分区：
文献类型：
--
作者：
BOOGERD, W;HUININK, WWT;VANDERSANDE, JJ
在接受顺铂治疗的患者中进行了一项前瞻性研究，以评价中枢、外周和自主神经病变的发生率和程度，并确定研究这种神经病变的最准确方法。12例患者在治疗前、治疗中和治疗后进行了检查。评估包括神经系统检查，正中神经和腓神经的常规神经传导研究和正中神经和胫神经刺激后的短潜伏期体感诱发电位（SSER）。11例患者在治疗前和治疗中进行了Valsalva动作。周围神经病变的症状超过临床体征。在确定周围神经病变方面，传统的神经传导研究似乎并不比临床检查更准确。SSER似乎是检测周围神经损伤的最敏感的方法。SSER测定的中枢传导速度在累积剂量200-400 mg/m2后出现减慢。在两名患者中，也有人建议自主神经的参与。
A prospective study was performed in patients treated with cisplatin to evaluate the occurrence and degree of central, peripheral and autonomic neuropathy and to determine the most accurate method to study this neuropathy. Twelve patients were examined before, during and after treatment. Evaluation included neurologic examination, conventional nerve conduction studies of the median and peroneal nerves and short latency somatosensory evoked potentials (SSER) after median and tibial nerve stimulation. Valsalva maneuvers before and during treatment were performed in 11 patients. Symptoms of peripheral neuropathy paralleled clinical signs. Conventional nerve conduction studies did not seem to be more accurate than clinical examination in determining peripheral neuropathy. SSER appeared to be the most sensitive method for the detection of peripheral nerve impairment. A slowing of central conduction velocity occurred after cumulative doses of 200–400 mg/m2as measured by SSER. In two patients also some involvement of the autonomic nerves was suggested.