GAMMA-DELTA-LYMPHOCYTES-T IN HUMAN TUBERCULOSIS
GAMMA-DELTA-LYMPHOCYTES-T IN HUMAN TUBERCULOSIS
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DOI：
10.1093/infdis/165.3.506
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发表时间：
1992-03-01
影响因子：
6.4
通讯作者：
MODLIN, RL
中科院分区：
文献类型：
--
作者：
BARNES, PF;GRISSO, CL;MODLIN, RL
The manifestations of tuberculous infection reflect the immune response to infection. Most healthy tuberculin reactors develop protective immunity; tuberculous pleuritis reflects a resistant response manifest by mild disease, whereas advanced pulmonary and miliary tuberculosis reflect ineffective immunity. The role of gamma-delta-T cells was assessed in tuberculous infection by evaluating expansion of these cells from blood mononuclear cells after stimulation with Mycobacterium tuberculosis. After culture in vitro, the percentages of gamma-delta+ cells were significantly greater in patients with protective and resistant immunity (tuberculin reactors, 25% +/- 4%; tuberculous pleuritis, 30% +/- 7%) than in those with ineffective immunity (advanced pulmonary tuberculosis, 9% +/- 3%; miliary tuberculosis, 2% +/- 1%). In leprosy, expansion of gamma-delta+ cells was greater in immunologically resistant tuberculoid patients (32% +/- 4%) than in Mycobacterium leprae-unresponsive lepromatous patients (9% +/- 2%). M. tuberculosis-reactive gamma-delta-T cell lines produced interferon-gamma, granulocyte-macrophage colony-stimulating factor, interleukin-3, and tumor necrosis factor-alpha, cytokines that activate macrophages and may contribute to mycobacterial elimination. These findings suggest that gamma-delta-T cells contribute to immune resistance against M. tuberculosis.
