Abnormalities of the uncinate fasciculus correlate with executive dysfunction in patients with left temporal lobe epilepsy
Abnormalities of the uncinate fasciculus correlate with executive dysfunction in patients with left temporal lobe epilepsy
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钩束异常与左颞叶癫痫患者执行功能障碍相关
DOI：
10.1016/j.mri.2015.02.011
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发表时间：
2015-06-01
影响因子：
2.5
通讯作者：
Yu, Lu
中科院分区：
文献类型：
--
作者：
Diao, Limei;Yu, Haichun;Yu, Lu
目的：评价左侧颞叶癫痫(TLE)患者的执行功能障碍，分析执行功能障碍与钩状神经束弥散张量成像(DTI)参数的关系。执行功能采用神经心理学测试，包括Stroop颜色词、数字广度、数字符号、连线测试和语言流畅性测试。结果：与对照组相比，癫痫患者在Stroop测验中所需时间(P=0.036)和错误答案(P<；0.001)显著增加，在数字广度(P=0.017)、数字符号(P=0.009)和词汇流畅性(P=0.001)测验中得分显著降低。此外，TLE患者完成测试所需的时间显著延长(P=0.042)。癫痫患者左侧钩束各向异性分数(FA)显著低于对照组(P<；0.001)。左侧钩束FA与语言流畅度(r=0.565，P=0.035；r=0.561，P=0.031)和数字广度(r=0.556，P=0.039；r=0.559，P=0.030)呈正相关。左侧UF与致痫带同侧的FA值异常提示左侧钩束的完整性受损与左侧TLE患者的执行缺陷有关。(C)2015 Elsevier Inc.保留所有权利。
Objective: To evaluate executive deficits in patients with left temporal lobe epilepsy (TLE) and to analyze the association of executive deficits and diffusion tensor imaging (DTI) parameters of the uncinate fasciculus.Methods: This study included 14 adult left TIE patients and 15 healthy controls. Executive function was examined using neuropsychological tests, including the Stroop color-word, digit span, digit symbol, trail-making test and verbal fluency tests. All subjects underwent brain DTI.Results: Compared with controls, TLE patients needed significantly more time (P = 0.036) and had more wrong answers (P < 0.001) in the Stroop test, and exhibited significantly lower scores in the digit span (P = 0.017), digit symbol (P = 0.009), and verbal fluency (P = 0.001) tests. Additionally, TLE patients took significantly longer to accomplish the trail-making test (P = 0.042). Fractional anisotropy (FA) of the left uncinate fasciculus in TLE patients was significantly lower compared to controls (P < 0.001). FA of the left uncinate fasciculus in TLE patients and controls positively correlated with verbal fluency (r = 0.565, P = 0.035; r = 0.561, P = 0.031) and digit span (r = 0.556, P = 0.039; r = 0.559, P = 0.030) test scores.Conclusions: Patients with left TLE exhibit wide ranges of executive deficits. Abnormal FA values in the left UF ipsilateral to the epileptogenic zone suggest that disrupted integrity in the left uncinate fasciculus is related to executive deficits in patients with left TLE. (C) 2015 Elsevier Inc. All rights reserved.