Head injury, diagnostic X-rays, and risk of medulloblastoma and primitive neuroectodermal tumor: a Children's Oncology Group study.
Head injury, diagnostic X-rays, and risk of medulloblastoma and primitive neuroectodermal tumor: a Children's Oncology Group study.
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头部损伤、诊断性 X 射线以及髓母细胞瘤和原始神经外胚层肿瘤的风险：儿童肿瘤学小组的一项研究。
DOI：
10.1007/s10552-010-9529-2
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Bunin,GretaR
中科院分区：
文献类型：
--
作者：
Khan,Saira;Evans,AlisonA;Rorke-Adams,Lucy;Orjuela,ManuelaA;Shiminski-Maher,Tania;Bunin,GretaR
目的对儿童常见脑肿瘤--髓母细胞瘤/原始神经外胚层肿瘤(PNET)的发病危险因素进行病例对照研究。这项分析通过诊断X射线和髓母细胞瘤/PNET评估了既往头部损伤与电离辐射暴露之间的可能联系。方法对1991年至1997年在儿童肿瘤学小组登记的318例6岁以下的确诊病例的母亲进行了访谈。结果未发现既往颅脑损伤史(OR：0.78，95%CI：0.40~1.5)与颅脑外伤合并髓母细胞瘤/PNET等头颅X线片的相关性。在统计上没有显著差异的病例报告有头部损伤以外的原因进行了X光检查(OR 2.3，95%CI 0.91-5.7)。当因髓母细胞瘤/PNET的常见症状而接受X光检查的患者被认为未暴露时，这种关联减弱(OR：1.3，95%CI：0.49-3.7)。未观察到剂量-反应关系。结论在本研究中，头部损伤和头部诊断X射线暴露与髓母细胞瘤/PNET无关。未来的研究应该调查电离辐射暴露的所有成像程序，包括计算机断层扫描，并利用辐射剂量估计。
ObjectiveA comprehensive case–control study was conducted to determine potential risk factors for medulloblastoma/primitive neuroectodermal tumor (PNET), a common brain tumor in children. This analysis evaluated possible associations between previous head injury and ionizing radiation exposure through diagnostic X-rays and medulloblastoma/PNET.MethodsMothers of 318 cases <6 years of age at diagnosis between 1991 and 1997 and registered with the Children’s Oncology Group were interviewed. Mothers of 318 matching controls were selected through random digit dialing and interviewed.ResultsAn association was not detected between previous head injury (OR: 0.78, 95% CI: 0.40–1.5) or head X-ray foranyreason including head injury with medulloblastoma/PNET. A statistically non-significant excess of cases reported having an X-ray for reason other than head injury (OR 2.3, 95% CI 0.91–5.7). When cases that received an X-ray for a common symptom of medulloblastoma/PNET were considered unexposed this association weakened (OR: 1.3, 95% CI: 0.49–3.7). No dose–response relationship was observed.ConclusionsHead injury and exposure to diagnostic head X-rays were not associated with medulloblastoma/PNET in this study. Future studies should investigate all imaging procedures with ionizing radiation exposure including computed tomography scans and utilize radiation dose estimations.