Transcriptomic and macroevolutionary evidence for phenotypic uncoupling between frog life history phases.
Transcriptomic and macroevolutionary evidence for phenotypic uncoupling between frog life history phases.
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DOI：
10.1038/ncomms15213
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发表时间：
2017-05-15
影响因子：
16.6
通讯作者：
Vences M
中科院分区：
文献类型：
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作者：
Wollenberg Valero KC;Garcia-Porta J;Rodríguez A;Arias M;Shah A;Randrianiaina RD;Brown JL;Glaw F;Amat F;Künzel S;Metzler D;Isokpehi RD;Vences M
无尾两栖动物在发育过程中经历了主要的形态转变，但它们明显不同的生活史阶段对宏观进化的贡献很少被分析。在这里，我们产生可检验的预测耦合与解耦的蝌蚪和成人的生活史阶段的表型进化，并为相关的基因表达的形态特征的形成。我们测试这些预测相结合的证据，从基因表达在两个远亲的青蛙，非洲爪蟾和Mantidactylus betsileanus，在整个辐射的马达加斯加mantellid青蛙形态进化的模式。与形态结构形成相关的基因以高度阶段特异性的模式表达，这表明表型进化在整个生活史阶段之间存在解偶联。这种基因表达模式同意解耦速率性状进化之间的生活史阶段的地幔，我们已经经历了适应性辐射。我们的研究结果验证了普遍的解偶联在蝌蚪和成年青蛙表型的进化。在具有复杂生命周期的动物中，一个生命阶段的选择可能会限制另一个阶段的适应。在这里，作者发现，在mantellid青蛙的适应性辐射，蝌蚪和成人形态的进化已经通过阶段特异性基因表达解耦。
Anuran amphibians undergo major morphological transitions during development, but the contribution of their markedly different life-history phases to macroevolution has rarely been analysed. Here we generate testable predictions for coupling versus uncoupling of phenotypic evolution of tadpole and adult life-history phases, and for the underlying expression of genes related to morphological feature formation. We test these predictions by combining evidence from gene expression in two distantly related frogs, Xenopus laevis and Mantidactylus betsileanus, with patterns of morphological evolution in the entire radiation of Madagascan mantellid frogs. Genes linked to morphological structure formation are expressed in a highly phase-specific pattern, suggesting uncoupling of phenotypic evolution across life-history phases. This gene expression pattern agrees with uncoupled rates of trait evolution among life-history phases in the mantellids, which we show to have undergone an adaptive radiation. Our results validate a prevalence of uncoupling in the evolution of tadpole and adult phenotypes of frogs. In animals with complex life cycles, selection on one life phase may constrain adaptation in another phase. Here the authors find that, during the adaptive radiation of mantellid frogs, the evolution of tadpole and adult morphologies has been uncoupled through phase-specific gene expression.