Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology.
Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology.
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DOI：
10.1016/j.tcb.2015.05.004
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发表时间：
2015-09
影响因子：
19
通讯作者：
Zhong Q
中科院分区：
文献类型：
--
作者：
Levine B;Liu R;Dong X;Zhong Q
Beclin直系同源物是自噬和相关膜运输途径的关键调节剂。多种信号通路汇聚在Beclin 1上，以调节细胞应激反应、膜运输和生理学。Beclin家族，包括酵母Atg 6（自噬相关基因6），其在高等真核生物物种中的直系同源物，以及最近表征的拟南芥特异性Beclin 2，是自噬和其他膜运输事件中的重要分子。对Beclin同源物的广泛研究为自噬的调节、自噬在生理学和疾病中的不同作用以及在各种临床疾病中调节自噬的潜在新策略提供了相当多的见解。在这篇综述中，我们讨论了Beclin同源物的功能，通过不同的细胞信号传导途径调节这些功能，以及这种调节对下游细胞过程包括肿瘤抑制和代谢的影响。这些发现表明，Beclin直系同源物是整合不同环境信号与膜运输事件的关键分子，以确保细胞对应激刺激的最佳反应。
Beclin orthologs are crucial regulators of autophagy and related membrane-trafficking pathways. Multiple signaling pathways converge on Beclin 1 to regulate cellular stress responses, membrane trafficking, and physiology. The Beclin family, including yeast Atg6 (autophagy related gene 6), its orthologs in higher eukaryotic species, and the more recently characterized mammalian-specific Beclin 2, are essential molecules in autophagy and other membrane-trafficking events. Extensive studies of Beclin orthologs have provided considerable insights into the regulation of autophagy, the diverse roles of autophagy in physiology and disease, and potential new strategies to modulate autophagy in a variety of clinical diseases. In this review we discuss the functions of Beclin orthologs, the regulation of such functions by diverse cellular signaling pathways, and the effects of such regulation on downstream cellular processes including tumor suppression and metabolism. These findings suggest that Beclin orthologs serve as crucial molecules that integrate diverse environmental signals with membrane trafficking events to ensure optimal responses of the cell to stressful stimuli.