The zitter mutant rat exhibits loss of D3 receptors with degeneration of the dopamine system
The zitter mutant rat exhibits loss of D3 receptors with degeneration of the dopamine system
复制标题
zitter 突变大鼠表现出 D3 受体缺失和多巴胺系统退化
DOI：
10.1097/00001756-200007140-00022
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发表时间：
2000
期刊：
影响因子：
1.7
通讯作者：
S. Ueda
中科院分区：
文献类型：
--
作者：
J. Joyce;K. Yoshimoto;S. Ueda
多巴胺（DA） D3受体调节的实验研究利用了导致DA系统大量消耗的技术。采用放射自显像法检测纹状体DA神经异质性缺失的Zitter突变大鼠的DA转运体（DAT）结合和DA D3受体数量，并与Sprague-Dawley大鼠进行比较。DAT结合的显著丢失在外侧尾状核-壳核中最大（丢失72%），在伏隔核中最少（丢失45%）。DA D3受体在所有区域都减少了70%，即使在表现出相当小的DAT结合消耗的伏隔核中也是如此，这表明D3受体的丢失可能发生在DA神经支配的大量丢失之前。
Experimental studies of the regulation of the dopamine (DA) D3 receptor have utilized techniques causing massive depletions of the DA system. Zitter mutant rats exhibiting a heterogeneous loss of striatal DA innervation were examined for DA transporter (DAT) binding and DA D3 receptor number by autoradiography and compared with Sprague-Dawley rats. A significant loss of DAT binding was observed with the greatest in the lateral caudate-putamen (72% loss) and the least in the nucleus accumbens (45% loss). DA D3 receptors were reduced by > 70% in all regions, even in the nucleus accumbens that exhibited considerably smaller depletions of DAT binding, indicating that loss of D3 receptors may occur prior to massive loss of DA innervation.
大鼠伏隔核和卡列哈岛 D3 多巴胺受体表达的发育调节。
DOI：
--
发表时间：
1999
期刊：
The Journal of pharmacology and experimental therapeutics.
影响因子：
--
作者：
Gurevich,EV;Himes,JW;Joyce,JN
通讯作者：
Joyce,JN