HIV and bone loss.
HIV and bone loss.
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DOI：
10.1007/s11914-010-0036-x
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发表时间：
2010-12-01
影响因子：
4.3
通讯作者：
Iqbal, Jameel
中科院分区：
文献类型：
--
作者：
Arora, Shitij;Agrawal, Manasi;Iqbal, Jameel
The use of antiretroviral therapy has significantly reduced the number of deaths due to HIV/AIDS. However, no current therapy can suppress the virus completely, and as the HIV-infected population continues to live longer new complications are emerging from the persistence of the virus and use of antiretroviral therapy. This review summarizes the clinical evidence linking HIV-associated osteoporosis to direct infection and antiretroviral therapy (ART) use. The purported molecular mechanisms involved in bone loss are also reviewed. Additionally, recommendations regarding the pharmacologic management of HIV/ART-related osteoporosis are given.
