Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus type 2 infection
Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus type 2 infection
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DOI：
10.1086/519693
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发表时间：
2007-08-15
影响因子：
6.4
通讯作者：
Wald, Anna
中科院分区：
文献类型：
--
作者：
Bochud, Pierre-Yves;Magaret, Amalia S.;Wald, Anna
生殖器单纯疱疹病毒2型（HSV-2）感染的临床和病毒学表现差异很大。我们研究了Toll样受体（TLR）2，3，4和9的单核苷酸多态性（SNP）的频率，在一个前瞻性队列的128例HSV-2感染者的病毒脱落和病变的频率进行了测量，每天从生殖器分泌物采样。两种TLR 2单倍型（2和4）与病变（P = 0.008和P = 0.03）和脱落（P = 0.02和P = 0.001）率增加相关。单倍型2（-15607A/G）中的SNP也与脱落（P = .01）和病变（P = .008）率相关。TLR 2的多态性可能是HSV-2感染严重程度差异的部分原因。
Clinical and virologic manifestations of genital herpes simplex virus type 2 (HSV-2) infection vary widely. We examined frequencies of single-nucleotide polymorphisms (SNPs) in Toll-like receptors (TLRs) 2, 3, 4, and 9 in a prospective cohort of 128 HSV-2-infected persons whose viral shedding and lesion frequency was measured by daily sampling from genital secretions. Two TLR2 haplotypes (2 and 4) were associated with increased lesional (P = .008 and P = .03) and shedding (P = .02 and P = .001) rates. An SNP in haplotype 2 (- 15607A/G) was also associated with shedding (P = .01) and lesional (P = .008) rates. Polymorphisms in TLR2 may be in part responsible for differences in the severity of HSV-2 infection.