Detection and characterization of two chimpanzee polyomavirus genotypes from different subspecies.
Detection and characterization of two chimpanzee polyomavirus genotypes from different subspecies.
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DOI：
10.1186/1743-422x-7-347
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发表时间：
2010-11-26
期刊：
影响因子：
4.8
通讯作者：
Verschoor EJ
中科院分区：
文献类型：
--
作者：
Deuzing I;Fagrouch Z;Groenewoud MJ;Niphuis H;Kondova I;Bogers W;Verschoor EJ
确定了三种黑猩猩多瘤病毒遗传变异体的完整核苷酸序列。系统发育分析表明，这两种病毒分别属于两种不同的ChPyV基因型。与其他灵长类多瘤病毒的比较显示了一个假定的未知基因，和一个异常长的VP1开放阅读框架。病毒的转录控制区（TCR）非常短（155个核苷酸），并且在基因型之间高度保守。对来自不同黑猩猩亚种的TCR和来自五个个体的一系列组织的分析证实了其遗传稳定性，并且还表明可能发生不同基因型的双重感染。
The complete nucleotide sequences of three chimpanzee polyomavirus genetic variants were determined. Phylogenetic analysis indicated that the viruses form two different genotypes of ChPyV. Comparison with other primate polyomaviruses revealed a putative agnogene, and an unusually long VP1 open reading frame. The transcriptional control regions (TCR) of the viruses were extremely short (155 nucleotides), and highly conserved amongst the genotypes. Analysis of the TCR from different chimpanzee subspecies, and from a series of tissues from five individuals confirmed its genetic stability, and also indicates that double-infections with different genotypes can occur.