Painful stimuli evoke potentials recorded from the parasylvian cortex in humans.
Painful stimuli evoke potentials recorded from the parasylvian cortex in humans.
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DOI：
10.1152/jn.1998.80.4.2077
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发表时间：
1998-10
影响因子：
2.5
通讯作者：
F. Lenz;M. Ríos;D. Chau;G. Krauss;T. Zirh;Ronald P. Lesser
中科院分区：
文献类型：
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作者：
F. Lenz;M. Ríos;D. Chau;G. Krauss;T. Zirh;Ronald P. Lesser
用CO2激光刺激3例清醒患者的面部和手部皮肤，记录了左侧大脑侧裂旁皮质的诱发电位（LEPs）。通过植入用于癫痫评估的硬膜下电极网格记录这些。对侧面部的刺激产生由负电位（N2，162 +/- 5 ms;平均值+/- SE）和随后的正电位（P2，340 +/- 18 ms）组成的波形。这两个波发生在较长的潜伏期后，手比面部刺激。从网格记录的N2和P2电位在形态上与用相同刺激范例测试的另外四名患者的头皮记录的电位良好对应。从硬膜下网格记录的N2波发生在明显短于头皮记录的潜伏期（184 +/- 6 ms），但网格处的P2波发生在明显长于头皮记录的潜伏期（281 +/- 13 ms）。从网格记录的电位的振幅是最大的顶骨盖对侧刺激的脸或手，并为同侧刺激的脸。在刺激同侧手后，也记录了该区域的电位。这些电位的皮层分布表明，它们的发生器位于顶骨盖或在小脑，或在两者，与以前的PET，脑磁图，和头皮LEP源分析一致。这些以前的分析提供了间接的证据，伤害性输入到侧裂旁皮层，因为每个分析的解释包括多个假设。目前的结果是第一个直接证据的伤害性输入到人类侧裂皮层。
Cutaneous stimulation of the face and hand with a CO2 laser in three awake patients evoked potentials (LEPs) recorded from the dominant left parasylvian cortex. These were recorded by means of a subdural grid of electrodes implanted for evaluation of epilepsy. Stimulation of the contralateral face resulted in waveforms consisting of a negative potential (N2, 162 +/- 5 ms; mean +/- SE) followed by a positive potential (P2, 340 +/- 18 ms). Both waves occurred at longer latency after hand than after facial stimulation. N2 and P2 potentials recorded from the grid correspond well in morphology to those recorded from the scalp in four additional patients tested with the same stimulation paradigm. The N2 waves recorded from the subdural grid occurred at significantly shorter latencies than did those recorded from the scalp (184 +/- 6 ms), but the P2 waves at the grid occurred at significantly longer latencies than did those recorded at the scalp (281 +/- 13 ms). The amplitudes of the potentials recorded from the grid were maximal over the parietal operculum both for contralateral stimulation of the face or hand and for ipsilateral stimulation of the face. Potentials also were recorded in this area after stimulation of the ipsilateral hand. The cortical distributions of these potentials suggest that their generators are located in the parietal operculum or in the insula, or in both, consistent with previous PET, magnetoencephalographic, and scalp LEP source analyses. These previous analyses provide indirect evidence of nociceptive input to parasylvian cortex because the interpretation of each analysis incorporates multiple assumptions. The present results are the first direct evidence of nociceptive input to the human parasylvian cortex.