Circulating microRNA expression is reduced in chronic kidney disease
Circulating microRNA expression is reduced in chronic kidney disease
复制标题
DOI：
10.1093/ndt/gfr485
复制
发表时间：
2011-11-01
影响因子：
6.1
通讯作者：
Gleadle, Jonathan M.
中科院分区：
文献类型：
--
作者：
Neal, Calida S.;Michael, Michael Z.;Gleadle, Jonathan M.
背景microRNAs（miRNAs）是基因表达的重要调控因子，在肾脏发育和疾病中发挥重要作用。它们存在于包括血液和尿液的生物流体中，并且可能具有信号传导作用和作为疾病生物标志物的潜力。我们检测了不同阶段慢性肾衰竭患者包括接受维持性血液透析治疗的患者的miRNAs水平。在重度慢性肾衰竭患者中，与轻度肾损害或肾功能正常的患者相比，总miRNA和特异性miRNA的循环水平降低。检测到的循环miRNA与估计的肾小球滤过率之间存在较强的相关性，而与慢性肾脏疾病的其他特征（如贫血和甲状旁腺功能亢进）的相关性较弱。这些发现对于使用循环miRNA作为肾损害个体的生物标志物和尿毒症的发病机制具有重要意义。
Background. MicroRNAs (miRNAs) are important regulators of gene expression, which have roles in renal development and disease. They exist in biological fluids including blood and urine and may have signalling roles and potential as disease biomarkers.Methods. We measured the levels of miRNAs in patients with different stages of chronic kidney failure including those receiving maintenance haemodialysis treatment.Results. In patients with severe chronic renal failure, circulating levels of total and specific miRNAs are reduced in comparison to patients with mild renal impairment or normal renal function. A strong correlation exists between detected circulating miRNAs and estimated glomerular filtration rate, and less strong correlations with other features of chronic kidney disease, such as anaemia and hyperparathyroidism.Conclusion. These findings have important implications for the use of circulating miRNAs as biomarkers in individuals with renal impairment and for the pathogenesis of uraemia.