Variability of gastrointestinal transit in healthy women and men
Variability of gastrointestinal transit in healthy women and men
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DOI：
10.1136/gut.39.2.299
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发表时间：
1996-08-01
期刊：
影响因子：
24.5
通讯作者：
Phillips, SF
中科院分区：
文献类型：
--
作者：
Degen, LP;Phillips, SF
背景和目的：胃肠转运的测量是在临床和研究胃肠病学中进行的，但其内在的变异性并不是很好的特征。特别是，荷尔蒙对运输的影响被认为是胃肠道症状的基础，胃肠道症状随月经周期而变化。我们的目的是量化健康女性在月经周期中的运输过程中的个体差异，并将这些差异与健康男性的内在变异性进行比较。方法-在两种情况下，整个肠道运输通过闪烁照相进行评估，结肠运输通过不透明放射标志物进行量化。32名健康志愿者(12名女性，20名男性)被研究，女性处于卵泡期和黄体期，男性在类似的四周内两次。饮食和锻炼在两个研究之前和期间都是标准化的。结果--男性的结肠传输明显更快，滞后后的胃排空也更快；其他区域传输指数在性别之间没有差异。总结肠通过时间同样可以通过闪烁照相和放射不透明标记物方法很好地反映。两种性别都注意到了重要的个体内差异。我们样本中的方差预测了80%的机会(以95%的置信度)检测到月经激素对经期的平均影响，这与男性的内在变异范围相同。结论--男性的结肠通过速度比女性快。尽管两项研究中的群体平均数几乎相同，但受试者对凌日的单一评估有时表现出相当大的差异，这意味着广泛的生物学差异。考虑到这种内在的变异性，月经激素对胃肠道转运的影响肯定很小，临床意义值得怀疑。
Background and Aims-Measurements of gastrointestinal transit are made in clinical and research gastroenterology, yet their intrinsic variability is not well characterised. In particular, an influence of hormones on transit has been proposed as the basis for gastrointestinal symptoms that vary with the menstrual cycle. Our aims were to quantify individual differences in transit during the menstrual cycle in healthy women and to compare these with the intrinsic variability in healthy men.Methods-On two occasions, whole gut transit was assessed scintigraphically and colonic transit quantified by radioopaque markers. Thirty two healthy volunteers (12 women, 20 men) were studied, women during the follicular and luteal phases, men twice within a similar four week period. Diets and exercise were standardised prior to and during both studies.Results-Colonic transit was significantly faster in men, and postlag gastric emptying was also more rapid; other indices of regional transit were not different between the sexes. Total colonic transit time was equally well reflected by the scintigraphic and radio-opaque marker methods. Important intraindividual differences were noted in both sexes. The variances in our samples predicted an 80% chance of detecting (with 95% confidence) a mean effect of menstrual hormones on transit that was in the same range as the intrinsic variation in men.Conclusions-Colonic transit was faster in men than in women. Although group means in the two studies were almost identical, single assessments of transit in subjects sometimes exhibited considerable variability, implying broad biological variations. Given this intrinsic variability, the influence of menstrual hormones on gastrointestinal transit must be small and of doubtful clinical significance.