Adverse effects of clozapine
Adverse effects of clozapine
复制标题
氯氮平的不良反应
DOI：
10.1007/bf00442571
复制
发表时间：
2004
影响因子：
3.4
通讯作者：
L. G. Schmidt
中科院分区：
文献类型：
--
作者：
R. Grohmann;Eckart Rüther;N. Sassim;L. G. Schmidt
与氯氮平相关的不良反应在两所大学精神病学系的上市后药物监测项目--AMäP研究中进行了评估。在随机选择的患者样本中(加强药物监测)，在接受氯氮平治疗的住院患者中，76%观察到任何类型的不良反应。镇静、过度兴奋、转氨酶升高和脑电改变是最常见的，但很少需要在治疗中改变。在参与医院的959名住院患者中，有8.1%的患者暴露于氯氮平，ADR导致停用氯氮平；3.9%的患者出现了严重的和潜在的生命威胁反应。在这些人当中，中毒性的精神错乱盛行。此外，使用氯氮平和苯二氮卓类药物联合用药，观察到4例严重的心血管和呼吸功能紊乱。这些病例和一例在氯氮平和氟哌啶醇治疗下猝死的病例被较详细地介绍。氯氮平的结果与其他抗精神病药物的药物监测项目的数据进行了比较。
Adverse effects related to clozapine were assessed within a post-marketing drug surveillance program, the AMÜP study, in two university psychiatric departments. In a randomly selected sample of patients (intensive drug monitoring) ADRs of any type were observed in 76% of clozapine-treated inpatients. Sedation, hypersalivation, increase in transaminases, and EEG changes were most frequently observed, but only rarely required changes in therapy. In 8.1% of 959 patients exposed to clozapine in the total inpatient population of the participating hospitals ADR led to withdrawal of clozapine; in 3.9% reactions judged as severe and potentially life-threatening occurred. Among these latter toxic delirium prevailed. In addition, four cases of severe cardiovascular and respiratory dysregulation were observed with the combination of clozapine and benzodiazepines. These cases and one case of sudden death under clozapine and haloperidol treatment are presented in some detail. The results obtained for clozapine are compared to data from this drug surveillance program for other neuroleptics.