Visible-Light-Induced Specific Desulfurization of Cysteinyl Peptide and Glycopeptide in Aqueous Solution
Visible-Light-Induced Specific Desulfurization of Cysteinyl Peptide and Glycopeptide in Aqueous Solution
复制标题
可见光诱导水溶液中半胱氨酰肽和糖肽的特异性脱硫
DOI：
10.1021/acs.orglett.6b00292
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发表时间：
2016-03-04
期刊：
影响因子：
5.2
通讯作者：
Guo, Jun
中科院分区：
文献类型：
--
作者：
Gao, Xiao-Fei;Du, Jing-Jing;Guo, Jun
已对可见光诱导的半胱氨酰肽的特异性脱硫进行了探索。由Ru(bpy)(3)(2+)催化的光催化脱硫能够在室温下于水溶液或水/有机溶剂的二元混合物中高效进行，并且与氨基酸残基、碳水化合物以及各种含硫官能团的存在相容。这种方法通过连接脱硫方案成功应用于线性和环状肽的合成。
Visible-light-induced specific desulfurization of cysteinyl peptides has been explored. The photocatalytic desulfurization catalyzed by Ru(bpy)(3)(2+) can proceed efficiently at room temperature in aqueous solution or in binary mixtures of aqueous/organic solvent and be compatible with the presence of residues of amino acids, carbohydrates, and various sulfur containing functional groups. This approach was successfully applied to synthesize linear and cyclic peptides through the ligation desulfurization protocol.