Systematic review of perchloroethylene and non-Hodgkin's lymphoma.
Systematic review of perchloroethylene and non-Hodgkin's lymphoma.
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DOI：
10.1016/j.gloepi.2022.100077
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发表时间：
2022-12
影响因子：
--
通讯作者：
Zhou, Jean
中科院分区：
文献类型：
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作者：
Goodman, Julie E;Ticknor, Rebecca C;Zhou, Jean
我们对评估四氯乙烯（PCE）与非霍奇金淋巴瘤（NHL）之间关联的流行病学研究进行了系统综述。这包括对研究质量的几个关键方面（即研究设计、暴露测量、暴露水平和潜在混杂因素）进行独立的详细评估，以及不太正式地考虑质量的其他方面。在已确定的15个独特队列的18项队列研究、14个独特人群组的17项病例对照研究以及3项生态学研究中，没有一项在所有四个关键质量要素上都是高质量的，而且每项研究还存在其他主要的方法学研究局限性。报告的风险估计值大多为零，范围从低于1到高于1不等，并且往往具有极宽的置信区间（CIs），表明风险估计值不稳定。此外，没有剂量 - 反应的一致证据。总体而言，鉴于现有流行病学研究质量较低，证据不支持四氯乙烯暴露与非霍奇金淋巴瘤之间存在关联。
We conducted a systematic review of epidemiology studies that evaluated the association between perchloroethylene (PCE) and non-Hodgkin's lymphoma (NHL). This included an independent detailed assessment of a few critical aspects of study quality (i.e., study design, exposure measurement, exposure levels, and potential confounding), and a consideration of other aspects of quality less formally. Of the identified 18 cohort studies of 15 unique cohorts, 17 case-control studies of 14 unique population groups, and 3 ecological studies, none was high quality for all four critical quality elements and each study also had other major methodological study limitations. Reported risk estimates were mostly null, ranged widely from below to above 1, and often had extremely wide confidence intervals (CIs), indicating unstable risk estimates. In addition, there was no consistent evidence of dose-response. Overall, given the low quality of the available epidemiology studies, the evidence does not support an association between PCE exposure and NHL.