Antibacterial activity of East African medicinal plants
Antibacterial activity of East African medicinal plants
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DOI：
10.1016/s0378-8741(97)00128-1
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发表时间：
1998-02-01
影响因子：
5.4
通讯作者：
Ansorg, R
中科院分区：
文献类型：
--
作者：
Fabry, W;Okemo, PO;Ansorg, R
在一项民族药理学调查中，（stem bark），Terminalia spinosa（幼枝）、Harrisonia abyssinica（根）、Ximenia caffra（根）、Azadirachta indica（茎皮和叶）和毛里求斯蜘蛛草（根和花）对来自七个属的105株细菌进行了测试（葡萄球菌属、肠球菌属、假单胞菌属、埃希氏菌属、克雷伯氏菌属、沙门氏菌属、分枝杆菌属）。结果表明，E. abyssinica、T. spinosa，刺叶木X. caffra和A. Indica（茎皮）的范围分别为0.13-8 mg/ml和0.5-> 8 mg/ml。它们的最低杀菌浓度（MBC 50%和MBC 90%）均在0.5 ~> 8 mg/ml之间。H. abyssinica、艾氏藻A. indica（leaves）和S.毛里求斯（根和花）的MIC和MBC值大于或等于8 mg/ml。在0.5-2 mg/ml的浸提液浓度下，分枝杆菌未受到抑制。可以得出结论，具有低MIC和MBC值的植物提取物可以作为具有治疗效力的化合物的来源。(C)1998爱思唯尔科学爱尔兰有限公司
In an ethnopharmacological survey, extracts of the six East African medicinal plants Entada abyssinica (stem bark), Terminalia spinosa (young branches), Harrisonia abyssinica (roots), Ximenia caffra (roots), Azadirachta indica (stem bark and leaves), and Spilanthes mauritiana (roots and flowers) were tested against 105 strains of bacteria from seven genera (Staphylococcus, Enterococcus, Pseudomonas, Escherichia, Klebsiella, Salmonella, Mycobacterium). The minimum inhibitory concentration reached by 50% (MIC50%) and 90% (MIC90%) of the strains for the extracts of E. abyssinica, T. spinosa, X. caffra, and A. indica (stem bark) ranged from 0.13-8 mg/ml and from 0.5 to > 8 mg/ml, respectively. Their minimum bactericidal concentration by 50% (MBC50%) and MBC90% were all between 0.5 and > 8 mg/ml. H. abyssinica, A. indica (leaves), and S. mauritiana (roots and flowers) had MIC and MBC values greater than or equal to 8 mg/ml. Mycobacteria were not inhibited at extract concentrations of 0.5-2 mg/ml. It is concluded that plant extracts with low MIC and MBC values may serve as sources for compounds with therapeutic potency. (C) 1998 Elsevier Science Ireland Ltd.