Fusidic acid is highly active against extracellular and intracellular Mycobacterium leprae.
Fusidic acid is highly active against extracellular and intracellular Mycobacterium leprae.
复制标题
夫西地酸对细胞外和细胞内麻风分枝杆菌具有高度活性。
DOI：
10.1128/aac.36.1.92
复制
发表时间：
1992
影响因子：
4.9
通讯作者：
Harris,EB
中科院分区：
文献类型：
--
作者：
Franzblau,SG;Biswas,AN;Harris,EB
在无菌培养基和小鼠腹腔巨噬细胞内的杆菌中研究了夫西地酸对麻风分枝杆菌的活性。通过随后定量细菌放射呼吸测定活性来评估活性。在0.156 μ g/ml浓度下观察到两种系统中的显著抑制作用，暴露于1.25 - 2.5 μ g/ml浓度后，活性降低约50%。夫西地酸对麻风杆菌的良好人体药代动力学和体外活性证明了该药物用于麻风病的临床试验。
The activity of fusidic acid against Mycobacterium leprae was studied in axenic medium and in bacilli residing within mouse peritoneal macrophages. Activity was assessed by subsequent quantitation of bacillary radiorespirometric activity. Significant inhibition in both systems was observed at 0.156 micrograms/ml, and an approximately 50% reduction in activity occurred after exposure to 1.25 to 2.5 micrograms/ml. The excellent human pharmacokinetics and in vitro activity of fusidic acid against the leprosy bacillus warrant a clinical trial of this drug for leprosy.