Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle?: A study of the gram-negative bacterium Escherichia coli
Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle?: A study of the gram-negative bacterium Escherichia coli
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DOI：
10.1128/aem.02218-06
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发表时间：
2007-03-01
影响因子：
4.4
通讯作者：
Song, Joon Myong
中科院分区：
文献类型：
--
作者：
Pal, Sukdeb;Tak, Yu Kyung;Song, Joon Myong
在这项工作中，我们研究了不同形状的银纳米颗粒在液体体系和琼脂平板上对革兰氏阴性杆菌大肠杆菌的抗菌性能。能量过滤的透射电子显微镜图像显示，治疗后细胞膜发生了相当大的变化，导致细胞死亡。以{111}晶格平面为基面的截断三角形银纳米板具有最强的杀菌作用，与球形和棒状纳米粒子以及以AgNO3形式存在的Ag+相比，具有最强的杀菌作用。有人提出，纳米尺寸和{111}面的存在结合起来促进了这种生物杀灭特性。据我们所知，这是第一次对不同形状的银纳米颗粒的杀菌性能进行比较研究，我们的结果表明，银纳米颗粒与革兰氏阴性菌发生了形状依赖的相互作用。
In this work we investigated the antibacterial properties of differently shaped silver nanoparticles against the gram-negative bacterium Escherichia coli, both in liquid systems and on agar plates. Energy-filtering transmission electron microscopy images revealed considerable changes in the cell membranes upon treatment, resulting in cell death. Truncated triangular silver nanoplates with a {111} lattice plane as the basal plane displayed the strongest biocidal action, compared with spherical and rod-shaped nanoparticles and with Ag+ (in the form of AgNO3). It is proposed that nanoscale size and the presence of a {111} plane combine to promote this biocidal property. To our knowledge, this is the first comparative study on the bactericidal properties of silver nanoparticles of different shapes, and our results demonstrate that silver nanoparticles undergo a shape-dependent interaction with the gram-negative organism E. coli.