THE ROLE OF CELLULAR PROLIFERATION IN AN EXPERIMENTAL-MODEL OF MASSIVE PERIRETINAL PROLIFERATION
THE ROLE OF CELLULAR PROLIFERATION IN AN EXPERIMENTAL-MODEL OF MASSIVE PERIRETINAL PROLIFERATION
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DOI：
10.1016/s0002-9394(14)77370-2
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发表时间：
1982-01-01
影响因子：
4.2
通讯作者：
RYAN, SJ
中科院分区：
文献类型：
--
作者：
FASTENBERG, DM;DIDDIE, KR;RYAN, SJ
将1万~ 75万个自体和同源真皮成纤维细胞移植到兔眼的玻璃体腔中，临床表现相同，导致视网膜周围大量增生。建立了注射细胞数量与视网膜牵拉程度之间的剂量-反应关系。第二阶段实验评估了福尔马林和一氧化碳照射对成纤维细胞引起牵引力视网膜脱离能力的影响。细胞增殖或达到一个临界质量的活细胞是必要的发展牵引力视网膜脱离。视网膜周围增生是人类视网膜再植手术失败的最常见原因。
Transplantation of 10,000 to 750,000 autologous and homologous dermal fibroblasts into the vitreous cavity of rabbit eyes resulted in identical clinical findings leading to massive periretinal proliferation. A dose-response relationship between the number of cells injected and the extent of retinal traction that developed was established. The 2nd phase of the experiment evaluated the effects of formalin and Co irradiation on the fibroblasts'' ability to cause traction retinal detachment. Cell proliferation or the attainment of a critical mass of living cells was necessary for the development of traction retinal detachment. [Periretinal proliferation is the most common cause of failure of retinal reattachment surgery in humans.].