C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteria.
C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteria.
复制标题
DOI：
10.1083/jcb.201911005
复制
发表时间：
2022-02-07
期刊：
影响因子：
--
通讯作者：
Martin MV
中科院分区：
文献类型：
--
作者：
Aguilera A;Berdun F;Bartoli C;Steelheart C;Alegre M;Bayir H;Tyurina YY;Kagan VE;Salerno G;Pagnussat G;Martin MV
Aguilera et al. show that ferroptosis, an oxidative and iron-dependent form of regulated cell death, plays an important role in the cyanobacterium Synechocystis sp. PCC 6803 in response to heat stress. Ferroptosis is an oxidative and iron-dependent form of regulated cell death (RCD) recently described in eukaryotic organisms like animals, plants, and parasites. Here, we report that a similar process takes place in the photosynthetic prokaryote Synechocystis sp. PCC 6803 in response to heat stress. After a heat shock, Synechocystis sp. PCC 6803 cells undergo a cell death pathway that can be suppressed by the canonical ferroptosis inhibitors, CPX, vitamin E, Fer-1, liproxstatin-1, glutathione (GSH), or ascorbic acid (AsA). Moreover, as described for eukaryotic ferroptosis, this pathway is characterized by an early depletion of the antioxidants GSH and AsA, and by lipid peroxidation. These results indicate that all of the hallmarks described for eukaryotic ferroptosis are conserved in photosynthetic prokaryotes and suggest that ferroptosis might be an ancient cell death program.
登录
查看更多内容
ACSL4 通过塑造细胞脂质成分来决定铁死亡敏感性。
影响因子：
14.8
作者：
Doll S;Proneth B;Tyurina YY;Panzilius E;Kobayashi S;Ingold I;Irmler M;Beckers J;Aichler M;Walch A;Prokisch H;Trümbach D;Mao G;Qu F;Bayir H;Füllekrug J;Scheel CH;Wurst W;Schick JA;Kagan VE;Angeli JP;Conrad M
通讯作者：
Conrad M
影响因子：
27.5
作者：
Esther Perez-Perez, M.;Martin-Figueroa, Eugenio;Florencio, Francisco J.
通讯作者：
Florencio, Francisco J.
影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
1.6
作者：
Ding, Yi;Gan, Nanqin;Song, Lirong
通讯作者：
Song, Lirong
影响因子：
6.9
作者：
Buchanan, BB;Luan, S
通讯作者：
Luan, S