Stealing the Keys to the Kitchen: Viral Manipulation of the Host Cell Metabolic Network.
Stealing the Keys to the Kitchen: Viral Manipulation of the Host Cell Metabolic Network.
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DOI：
10.1016/j.tim.2015.08.007
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发表时间：
2015-12
影响因子：
15.9
通讯作者：
Munger J
中科院分区：
文献类型：
--
作者：
Goodwin CM;Xu S;Munger J
宿主细胞具有病毒感染所需的代谢资产。最近的研究表明，宿主代谢资源的控制是宿主-病原体相互作用的核心。病毒已经进化出一种机制来篡夺宿主的代谢资源，将它们汇集到病毒粒子组件的生产中，并组织专门的区室进行复制、成熟和传播。因此，宿主已经发展出多种代谢对策来感知和抵抗这些病毒的变化。病毒和宿主在代谢控制方面的复杂相互作用才刚刚开始被解开。然而，很明显，病毒诱导的代谢重编程可以显著影响感染结果，突出了针对这些过程进行抗病毒治疗开发的希望。许多病毒调节宿主细胞的代谢过程，以确保成功感染。宿主细胞代谢网络提供产生感染性病毒粒子所需的能量、前体和特殊成分。病毒利用宿主细胞代谢活动来组织病毒成熟区室。代谢控制是一种宿主-病原体相互作用，可以影响病毒感染的结果。
Host cells possess the metabolic assets required for viral infection. Recent studies indicate that control of the host's metabolic resources is a core host–pathogen interaction. Viruses have evolved mechanisms to usurp the host's metabolic resources, funneling them towards the production of virion components as well as the organization of specialized compartments for replication, maturation, and dissemination. Consequently, hosts have developed a variety of metabolic countermeasures to sense and resist these viral changes. The complex interplay between virus and host over metabolic control has only just begun to be deconvoluted. However, it is clear that virally induced metabolic reprogramming can substantially impact infectious outcomes, highlighting the promise of targeting these processes for antiviral therapeutic development. Numerous viruses modulate host-cell metabolic processes to ensure successful infection. The host-cell metabolic network contributes the energy, precursors, and specialized components necessary to produce infectious virions. Viruses deploy host-cell metabolic activities to organize viral maturation compartments. Metabolic control is a host–pathogen interaction that can sway the outcome of viral infection.