Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation.
Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation.
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萝卜硫素通过 Nrf2 激活预防心血管疾病。
DOI：
10.1155/2015/407580
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发表时间：
2015
影响因子：
--
通讯作者：
Zheng Y
中科院分区：
文献类型：
--
作者：
Bai Y;Wang X;Zhao S;Ma C;Cui J;Zheng Y
心血管疾病（CVD）在全球疾病负担中所占比例无与伦比，在不久的将来仍将是死亡的主要原因。氧化应激在心脏疾病的病理生理学中起主要作用。一些研究已经强调了活性氧或氮物质的过度产生在缺血性心肌损伤和随后的心功能不全的发病机制中所起的重要作用。异硫氰酸酯（ITC）是广泛分布于十字花科蔬菜中的含硫化合物。萝卜硫素（SFN）是一种ITC，体内和流行病学研究均表明其具有抗癌活性。最近的数据表明，SFN在CVD中的有益作用是由于其抗氧化和抗炎特性。SFN激活NF-E2相关因子2（Nrf 2），这是一种碱性亮氨酸拉链转录因子，通过诱导100多种细胞保护蛋白（包括抗氧化剂和II相解毒酶），作为对抗氧化应激和亲电子毒物的防御机制。本文综述了SFN调节Nrf 2激活和保护心血管疾病的潜在机制的临床研究和动物实验证据。
Cardiovascular disease (CVD) causes an unparalleled proportion of the global burden of disease and will remain the main cause of mortality for the near future. Oxidative stress plays a major role in the pathophysiology of cardiac disorders. Several studies have highlighted the cardinal role played by the overproduction of reactive oxygen or nitrogen species in the pathogenesis of ischemic myocardial damage and consequent cardiac dysfunction. Isothiocyanates (ITC) are sulfur-containing compounds that are broadly distributed among cruciferous vegetables. Sulforaphane (SFN) is an ITC shown to possess anticancer activities by both in vivo and epidemiological studies. Recent data have indicated that the beneficial effects of SFN in CVD are due to its antioxidant and anti-inflammatory properties. SFN activates NF-E2-related factor 2 (Nrf2), a basic leucine zipper transcription factor that serves as a defense mechanism against oxidative stress and electrophilic toxicants by inducing more than a hundred cytoprotective proteins, including antioxidants and phase II detoxifying enzymes. This review will summarize the evidence from clinical studies and animal experiments relating to the potential mechanisms by which SFN modulates Nrf2 activation and protects against CVD.