Correlation of Pancreatic T1 Values Using Modified Look-Locker Inversion Recovery Sequence (MOLLI) with Pancreatic Exocrine and Endocrine Function
Correlation of Pancreatic T1 Values Using Modified Look-Locker Inversion Recovery Sequence (MOLLI) with Pancreatic Exocrine and Endocrine Function
复制标题
改良Look-Locker倒置恢复序列(Molli)测定胰腺T1值与胰腺内、外分泌功能的相关性
DOI：
10.3390/jcm9061805
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发表时间：
2020-06-01
影响因子：
3.9
通讯作者：
Fujinaga, Yasunari
中科院分区：
文献类型：
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作者：
Ashihara, Norihiro;Watanabe, Takayuki;Fujinaga, Yasunari
量化心肌T1值对于检测和表征心肌梗死、局灶性瘢痕和非缺血性心肌病中的纤维化外观是有用的。由于胰腺外分泌功能随着慢性胰腺纤维化进展而降低，因此本研究检查了胰腺T1值与胰腺外分泌和内分泌功能不全之间的相关性。方法：32例患者于2017年10月至2019年2月在我科接受腹部增强MRI检查。我们使用改良的Look-Blocks倒置恢复序列（MOLLI）评估胰腺的T1值，通过粪便弹性蛋白酶1（FE1）值评估胰腺外分泌功能不全（PEI），并使用空腹胰岛素和血糖水平评估胰腺内分泌功能不全以计算HOMA-β。本试验在UMIN临床试验注册中心注册为UMIN 000030067。结果：中位队列（9名男性和23名女性）年龄为71岁（范围：49 - 84）。18名患者患有胰腺囊肿，3名患有酒精诱导的慢性胰腺炎，3名患有胰腺癌，8名患者具有其他胰腺特征（2名患者患有自身免疫性胰腺炎，急性胰腺炎或胆管肿瘤，1名患有特发性慢性胰腺炎，1名健康对照阴性）。通过MOLLI测量的中位胰腺T1值为857.5 ms（597 - 2569）。T1标测与FE1值呈显著负相关（r = 0.69，p <0.01），与HOMA-β或血清白蛋白、甘油三酯或体重指数无相关性。结论：胰腺T1值与胰腺外分泌功能密切相关，对PEI的诊断有一定的参考价值。
Quantifying myocardial T1 values has been useful for detecting and characterizing fibrotic appearance in myocardial infarction, focal scars, and non-ischemic cardiomyopathies. Since pancreatic exocrine function decreases with chronic pancreatic fibrosis advancement, this study examined the correlation between pancreatic T1 values and pancreatic exocrine and endocrine insufficiency. Methods: Thirty-two patients underwent abdominal contrast-enhanced MRI in our department between October 2017 and February 2019. We evaluated the T1 values of the pancreas using a modified Look-Locker inversion recovery sequence (MOLLI), pancreatic exocrine insufficiency (PEI) by fecal elastase 1 (FE1) values, and pancreatic endocrine insufficiency using fasting insulin and blood glucose levels to calculate the HOMA-beta. This trial is registered in the UMIN Clinical Trials Registry as UMIN 000030067. Results: The median cohort (9 males and 23 females) age was 71 (range: 49-84) years. Eighteen patients had pancreatic cysts, three had alcohol-induced chronic pancreatitis, three had pancreatic cancer, and eight possessed other pancreatic features (two patients each with autoimmune pancreatitis, acute pancreatitis, or a bile duct tumor, one with idiopathic chronic pancreatitis, and one healthy control with negative findings). The median pancreatic T1 value measured by the MOLLI was 857.5 ms (597-2569). A significant negative correlation was found between the T1 mapping and FE1 values (r = 0.69,p< 0.01), with none for the T1 with HOMA-beta or serum albumin, triglycerides, or body mass index. Conclusions: the pancreatic T1 values correlated significantly with pancreatic exocrine function and might be useful in PEI diagnosis.