Resolution of inflammation in neuromyelitis optica spectrum disorders
Resolution of inflammation in neuromyelitis optica spectrum disorders
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视神经脊髓炎谱系疾病炎症的解决
DOI：
10.1016/j.msard.2018.09.040
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发表时间：
2019
影响因子：
4
通讯作者：
Zhu Mingqin
中科院分区：
文献类型：
--
作者：
Wang Xu;Jiao Wenyu;Lin Meng;Lu Chao;Liu Caiyun;Wang Ying;Ma Di;Wang Xiuzhe;Yin Ping;Feng Jiachun;Zhu Jie;Zhu Mingqin
背景视神经肌萎缩症谱系障碍（Neuromyelodioptica spectrum disorders，NMOSD）是一系列与水通道蛋白4（aquaporin-4，AQP 4）抗体相关的神经炎症性疾病。越来越多的证据表明炎症参与了NMOSD的发病机制。炎症的消退是由专门的促消退脂质介质（SPM）介导的高度调节的过程，对于防止过度反应性炎症是重要的。炎症消退不足可能导致或加速炎症性疾病。然而，尚不清楚NMOSD中炎症的消退是否会受损。本研究的目的是分析NMOSD患者血清和脑脊液（CSF）中SPMs的水平，并探讨SPMs在NMOSD.Methods35例NMOSD患者，34例多发性硬化症患者和36例非炎症性神经系统疾病患者的临床特征中的作用。促消退介质包括膜联蛋白A1（ANXA 1）和消退素D1（RvD 1），以及促炎症脂质介质白三烯B4（LTB 4）水平通过酶联免疫吸附试验进行了分析。促炎细胞因子和抗炎细胞因子以及趋化因子水平进行了分析，使用流式细胞仪珠阵列（CBA）。结果我们的结果显示RvD 1水平显着下降，而LTB 4水平显着增加，在NMOSD患者的CSF。AQP 4-IgG滴度与NMOSD patients.ConclusionsDecreased RvD 1 levels in the CSF中RvD 1水平呈负相关，表明NMOSD patients中炎症的消退受损。AQP 4-IgG可能导致NMOSD中炎症增加并导致未解决的炎症。
BackgroundNeuromyelitis optica spectrum disorders (NMOSD) are a spectrum of neuroinflammatory disorders associated with autoimmune antibodies against aquaporin-4 (AQP4). Accumulating evidence suggests that inflammation is involved in NMOSD pathogenesis. Resolution of inflammation, which is a highly regulated process mediated by specialized pro-resolving lipid mediators (SPMs) is important to prevent over-responsive inflammation. Deficiency in resolution of inflammation may lead to or accelerates inflammatory diseases. However, whether resolution of inflammation is impaired in NMOSD is not known. The objective of this study was to analyze the levels of SPMs in the serum and cerebrospinal fluid (CSF) of NMOSD patients, and to explore the roles of SPMs in clinical features of NMOSD.MethodsThirty-five patients with NMOSD, 34 patients with multiple sclerosis, and 36 patients with non-inflammatory neurological diseases were enrolled in this study. Pro-resolving mediators including Annexin A1 (ANXA1) and resolvin D1 (RvD1), as well as pro-inflammatory lipid mediator leukotriene B4 (LTB4) levels were analyzed by enzyme-linked immunosorbent assay. Pro- and anti-inflammatory cytokines as well as chemokine levels were analyzed using cytometric beads array (CBA).ResultsOur results showed RvD1 levels were significantly decreased, whereas LTB4 levels were significantly increased in the CSF of NMOSD patients. AQP4-IgG titer was negatively correlated with RvD1 levels in the CSF of NMOSD patients.ConclusionsDecreased RvD1 levels indicate impaired resolution of inflammation in NMOSD patients. AQP4-IgG may contribute to increased inflammation and lead to unresolved inflammation in NMOSD.