Direct Observation and Manipulation of Supramolecular Polymerization by High-Speed Atomic Force Microscopy
Direct Observation and Manipulation of Supramolecular Polymerization by High-Speed Atomic Force Microscopy
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DOI：
10.1002/anie.201809165
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发表时间：
2018-11-19
影响因子：
16.6
通讯作者：
Sugiyasu, Kazunori
中科院分区：
文献类型：
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作者：
Fukui, Tomoya;Uchihashi, Takayuki;Sugiyasu, Kazunori
尽管近年来在合成超分子组装体的机理理解和控制合成方法方面取得了进展，但在真实的时间内捕获分子水平的现象仍然具有挑战性，从而阻碍了该研究领域的进一步发展。在这项研究中，我们应用高速原子力显微镜（AFM），它具有非凡的时空分辨率（1纳米和100毫秒以下），捕捉动态事件发生在合成分子自组装。高速原子力显微镜允许可视化独特的动态行为，如种子生长和自我修复在真实的时间。此外，扫描探针原子力显微镜允许位点特异性操作和功能化的分子自组装。这种自下而上和自上而下的方法在分子水平上的强大组合应该能够有针对性地合成前所未有的功能纳米结构。
Despite recent advances in mechanistic understanding and controlled-synthesis methodologies regarding synthetic supramolecular assemblies, it has remained challenging to capture the molecular-level phenomena in real time, thus hindering further progress in this research field. In this study, we applied high-speed atomic-force microscopy (AFM), which has extraordinary spatiotemporal resolution (1 nm and sub-100 ms), to capture dynamic events occurring during synthetic molecular self-assembly. High-speed AFM permitted the visualization of unique dynamic behavior, such as seeded growth and self-repair in real time. Furthermore, scanning-probe AFM permitted the site-specific manipulation and functionalization of a molecular self-assembly. This powerful combination of bottom-up and top-down approaches at the molecular level should enable targeted syntheses of unprecedented functional nanoarchitectures.